References: Lecithin
Immunopharmacol Immunotoxicol. 1992;14(1-2):129-39.
The effect of the synthetic lecithin analogue, dimethyl-DL-2, 3-distearolyoxypropyl-2'hydroxylethylammonium acetate, on cytolytic T lymphocyte (CTL) activity.
Lindquist RR.
University of Connecticut School of Medicine, Farmington 06030.
The effect of the synthetic lecithin analogue, dimethyl-DL-2, 3-distearolyoxypropyl-2'hydroxylethylammonium acetate, on CTL cytolytic activity was studied. The analogue significantly inhibits H-2b anti H-2d cytolytic T lymphocytes at concentrations which do not impair lymphocyte viability, protein synthesis, or RNA synthesis. At these concentrations the inhibition is reversible upon removing the analogue. Thus, the inhibition produced by analogue simply is not a result of analogue toxicity. At higher concentrations of the analogue, CTL inhibition is very pronounced; however at these higher concentrations there is evidence of non-specific toxicity of the analogue on CTL.
Laxative online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1597652&dopt=Abstract lecithin
J Parasitol. 1992 Jun;78(3):387-92.
Effects of cholinergic agents on the metabolism of choline in muscle from Ascaris suum.
Arevalo JI, Saz HJ.
Department of Biological Sciences, University of Notre Dame, Indiana 46556.
The incorporation of [methyl-14C]choline into the choline-containing compounds of Ascaris suum muscle and the effects of acetylcholine and its agonists, carbachol and levamisole, on this incorporation were studied. Previous experiments reported a stimulation of phosphatidylcholine (lecithin) metabolism upon the administration of acetylcholine. Acetylcholine administered in vitro to A. suum muscle and body wall preparations resulted in a stimulation of phospholipase C activity that, in turn, produced an increased rate of hydrolysis of phosphatidylcholine to the corresponding diacylglyceride (DAG). The DAG, in turn, may act as a second messenger as it is required for the activation of an A. suum protein kinase C. Evidence presented here is in accordance with this hypothesis. The administration of cholinergics resulted in a stimulation of phosphatidylcholine turnover. Acetylcholine also stimulated isotope incorporation into glycerophosphorylcholine, presumably as a consequence of enhanced phospholipid turnover. These events appear to be associated with the ligand binding to the acetylcholine receptors of the A. suum muscle. Choline kinase activity is suggested in order to maintain the observed high ratio of phosphorylcholine to choline. Findings indicate that in the parasite's muscle phosphatidylcholine metabolism may be linked to receptor-dependent responses and subsequent signal transduction.
Laxative online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1597777&dopt=Abstract lecithin
Int J Clin Lab Res. 1996;26(4):224-8.
Apolipoprotein AIV of human interstitial fluid is associated with apolipoprotein AI-containing but not with AII-containing particles.
Ghalim N, Adlouni A, Saile R, Parra HJ, Benslimane A, Bard JM, Fruchart JC.
Laboratoire des Lipoproteines, Institut Pasteur du Maroc, Casablanca, Morocco.
Apolipoproteins and lipoprotein particles from human interstitial fluid and plasma were analyzed. The interstitial fluid was enriched in apolipoproteins AI, AII, and AIV compared with apo B, apo CIII, and apo E, LpAI was found to contain apo AIV which was absent from LpAI: AII. Moreover, the bulk of lecithin-cholesterol acyl-transferase was present in LpAI. The concentration range of these particles was in agreement with those required in vitro for cholesterol efflux. Thus the interstitial fluid contains particles in which two agonists but no antagonists of cholesterol efflux are associated with lecithin-cholesterol acyltransferase activity. This supports apolipoprotein AI- and/or AIV-containing particles playing a critical role in the first step of reverse cholesterol transport.
Laxative online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9007611&dopt=Abstract lecithin
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