References: Lecithin
J Enzyme Inhib. 1997 Aug;12(3):227-40.
Uptake of the phospholipase A2 inhibitor 1-dodecyl 2-[1-14C] octanamido-sn-2-deoxy glycero-3-phosphocholine by peritoneal macrophages.
Bourass J, Boucrot P, Letourneux Y, Gandemer G, Petit JY.
Laboratoire de synthese et d'etude des substances naturelles a activite biologique, pole sciences, La Rochelle, France.
The [14C] phospholipid analogue 1-dodecyl-2-[1-14C] octanamido-sn-2-deoxy glycero-3-phosphocholine was synthetized. With 2 short fatty chains linked by alkyl and amido bonds to positions 1 and 2 of the glycerophosphate backbone, it was an inhibitor of phospholipase A2 in ionophore A23187-stimulated macrophages. Its uptake by rat peritoneal macrophages and its resistance towards phospholipases A2 were determined at nanomolar or micromolar concentrations in the culture medium. A control substrate for phospholipases A2 activity was established with the lecithin 1-octadecanoyl 2-[3H] eicosatetraenoyl-sn-glycero-3-phosphocholine ([3H] 20:4-GPC), a source of [3H] arachidonic acid after cleavage at position 2. Non-stimulated- or ionophore A23187-stimulated macrophages incorporated extensively the [14C] phospholipid analogue added at 30-4000 nM. At 4000 nM which induced 50% inhibition of the phospholipase, 40% of the dose was found associated with the [14C] phospholipids of 2 x 10(6) stimulated macrophages after 120 min incubation, while only low amounts of [14C] non-phosphorous lipids were detected. It is concluded that the [14C] phospholipid analogue was readily taken up by the macrophages with limited hydrolysis.
Laxative online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9314117&dopt=Abstract lecithin
Int Arch Allergy Immunol. 1992;97(4):345-9.
Immunoreactivity of a mammalian liver component with leprosy sera.
Deshpande RG, Khan MB, Navalkar RG.
Department of Microbiology and Immunology, Morehouse School of Medicine, Atlanta, Ga. 30310.
Sera from 77 leprosy patients in various stages of infection--tuberculoid (TT), lepromatous (LL), borderline tuberculoid and borderline lepromatous--15 contacts and 21 normal healthy individuals, were assayed in an indirect enzyme-linked immunosorbent assay and dot enzyme immunoassay using ethanol-soluble and thermostable extract of liver as the antigen. The highest incidences of reaction were found in untreated LL patients (100%) and in TT patients (91%), while the sera from borderline patients showed a comparatively lower incidence (43%). Some of the sera from contacts of leprosy patients (6/15) also showed high reactivity. Assays using lecithin as an antigen did not exhibit any reaction.
Laxative online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1597354&dopt=Abstract lecithin
J Dairy Sci. 1992 May;75(5):1313-9.
Changes in lipid composition of calf tissues by excess dietary zinc.
Jenkins KJ, Kramer JK.
Centre for Food and Animal Research, Agriculture Canada, Ottawa, ON.
In a previous study, very high Zn (1000 ppm) prevented most of the tissue lipid increases caused by very high Cu (1000 ppm), and this investigation was conducted to study whether Zn had a direct effect on lipid metabolism or simply acted indirectly by inhibiting excess Cu activity. Calves were fed basal dietary Cu (10 ppm), and lipid composition of heart, liver, and blood plasma was measured as affected by control (40 ppm in DM), high (500 ppm), or very high (1000 pm) Zn intakes. Supplementation with 1000 ppm of Zn did not cause any marked quantitative changes in tissue lipids (e.g., lipid classes, oleic, or stearic acids), suggesting that, in the previous study, Zn had mainly interfered with excess Cu effects on lipids rather than with lipid metabolism directly. However, there were two exceptions. Adding 1000 ppm of Zn to basal Cu ration 1) reduced concentration and changed the fatty acid composition of plasma cholesterol esters, both of which are indicative of excess Zn inhibiting lecithin:cholesterol acyltransferase activity, and 2) altered the desaturation and elongation of the essential fatty acids and their concentration in tissue phospholipids. This latter effect of excess Zn conceivably could be important in changing the structure and function of cell membranes and in the production and activity of prostanoids and leukotrienes.
Laxative online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1597586&dopt=Abstract lecithin
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