References: Lecithin
Presse Med. 1992 Jan 25;21(3):109-12.
[Changes in plasma lipoproteins in Mediterranean boutonneuse fever]
[Article in French]
el Amrani Marini A, Aranegui Lasuen P, Barcelo Valcarcel JM, Giner Escobar P, Corrales Torres A, Jimenez Alonso J.
Service de Medecine interne, HG Virgen de las Nieves, Granada, Espagne.
We report 25 cases of boutonneuse fever with, in the acute phase, an increase of plasma transaminases, triglycerides and apoprotein B levels, a decrease of total, HDL and LDL cholesterol and a decrease of apoprotein A. These changes disappeared 1 to 4 weeks after the beginning of treatment. They might be due to a reduced activity of lecithin-cholesterol acetyltransferase and lipoprotein lipase, probably caused by the hepatic and vascular disorders frequently found in this disease.
Laxative online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1347656&dopt=Abstract lecithin
Res Vet Sci. 1993 Sep;55(2):162-72.
Evaluation of free or liposome-encapsulated ribavirin for antiviral therapy of experimentally induced feline infectious peritonitis.
Weiss RC, Cox NR, Martinez ML.
Scott-Ritchey Research Center, College of Veterinary Medicine, Auburn University, Alabama 36849.
Ribavirin, either free in aqueous solution or incorporated into liposomes, was evaluated in 50 specific-pathogen-free kittens after experimental challenge exposure with feline infectious peritonitis virus (FIPV). Ribavirin was administered daily for 10 to 14 days at 16.5 mg kg-1 bodyweight given per os, intramuscularly or intravenously beginning 18 hours after kittens were challenge-exposed with FIPV. All kittens, including ribavirin-treated and untreated kittens, succumbed to FIP. Clinical signs of disease were more severe in the ribavirin-treated kittens and their mean survival times were shortened. The clinical efficacy of free ribavirin given intravenously at a reduced dosage (5.5 mg kg-1 bodyweight) was compared to that of ribavirin incorporated into lecithin-containing liposomes (5 mg kg-1) intravenously. Drugs were given once daily for three consecutive days of each week for three weeks, beginning 18 hours after virus challenge exposure. There was no significant difference either in survival rate or severity of disease between kittens given free ribavirin, liposomal ribavirin or saline only. Because of its intrinsic toxicity and low therapeutic index against FIPV and its marginal antiviral activities in vivo at maximal doses, ribavirin cannot presently be recommended as primary antiviral chemotherapy against FIP.
Laxative online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8235082&dopt=Abstract lecithin
Gastroenterology. 1992 Dec;103(6):1916-24.
Comparison of different treatment modalities in experimental pancreatitis in rats.
Kimura W, Meyer F, Hess D, Kirchner T, Fischbach W, Mossner J.
Department of Pathology, University of Wurzburg, Germany.
Lipolytic enzymes may play a role in the pathogenesis of acute pancreatitis. Therefore, the effects of a lipase inhibitor, THL (tetrahydrolipstatin), a protease inhibitor, FUT (nafamostat mesilate), and albumin under different conditions in rats were investigated. (a) Isolated pancreatic acini were incubated with pancreatic homogenates and triglycerides or lecithin with or without albumin and the degree of cellular destruction quantitated. (b) Taurocholate was injected into the pancreatic duct of isolated pancreas and the organ continuously perfused with either FUT, THL, or albumin. Organ damage was evaluated by measurement of pancreatic enzymes in the portal effluence. (c) Necrotizing pancreatitis was induced in vivo via retrograde taurocholate injection. FUT, THL, or albumin was applied either intravenously or injected into the pancreatic parenchyma. (a) Albumin prevented the cellular damage caused by both fatty acids and lysolecithin. (b) THL was ineffective, FUT lowered the release of pancreatic enzymes into the portal effluence, and albumin was most effective. (c) Albumin prevented the development of panlobular necrosis and lowered the degree of extrapancreatic fat necrosis. Albumin, via its ability to bind detergents, may have therapeutic implications.
Laxative online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1451985&dopt=Abstract lecithin
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