References: Lecithin
Patol Fiziol Eksp Ter. 1994 Jan-Mar;(1):19-20.
[Thrombin-induced platelet aggregation in the presence of negatively charged liposomes]
[Article in Russian]
Zakrevskii VI, Kubatiev AA.
The negatively charged liposomes of different phospholipid composition were examined for their effects on platelet aggregation induced in vitro by thrombin. Negatively charged dicetylphosphate and phosphatidylinositol failed to affect the aggregation of platelet suspension. The liposomes that contain yolk lecithin-phosphatidylserine-cholesterol (4:4:2) caused a dose-dependent increase in their aggregation. Replacement of yolk lecithin by dipalmitoylphosphatidylcholine eliminated the activating effect of phosphatidylserine. It is suggested that platelet activation is associated with the transfer of phosphatidylserine from liposomes to cells.
Laxative online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8183584&dopt=Abstract lecithin
Biol Reprod. 1995 Mar;52(3):625-30.
Origin of estradiol fatty acid esters in human ovarian follicular fluid.
Pahuja SL, Kim AH, Lee G, Hochberg RB.
Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06510, USA.
The estradiol fatty acid esters are the most potent of the naturally occurring steroidal estrogens. These esters are present predominantly in fat, where they are sequestered until they are hydrolyzed by esterases. Thus they act as a preformed reservoir of estradiol. We have previously shown that ovarian follicular fluid from patients undergoing gonadotropin stimulation contains very high amounts of estradiol fatty acid esters (approximately 10(-7) M). The source of these esters is unknown. They can be formed by esterification of estradiol in the follicular fluid by lecithin:cholesterol acyltransferase (LCAT), or in the ovary by an acyl coenzyme A:acyltransferase. In order to determine which of these enzymatic processes is the source of the estradiol esters in the follicular fluid, we incubated [3H]estradiol with follicular fluid and cells isolated from human ovarian follicular fluid and characterized the fatty acid composition of the [3H]estradiol esters biosynthesized in each. In addition, we characterized the endogenous estradiol fatty acid esters in the follicular fluid and compared them to the biosynthetic esters. The fatty acid composition of the endogenous esters was different than those synthesized by the cellular acyl coenzyme A:acyltransferase, and the same as the esters synthesized by LCAT, demonstrating that the esters are produced in situ in the follicular fluid. Although the role of these estradiol esters in the ovary is not known, given their remarkable estrogenic potency it is highly probable that they have an important physiological role.
Laxative online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7756456&dopt=Abstract lecithin
Chem Phys Lipids. 1994 Jan;69(1):75-85.
Fluorescence study of a derivatized diacylglycerol incorporated in model membranes.
Prieto MJ, Castanho M, Coutinho A, Ortiz A, Aranda FJ, Gomez-Fernandez JC.
Centro de Quimica Fisica Molecular, IST, Lisboa, Portugal.
A fluorescence study of a diacylglycerol derivatized with the n-(7-nitrobenz-2-oxa-1,3-diazol-4-yl) chromophore (NBD) was carried out. Fluorescence self-quenching was observed for this probe in lecithin model membranes due to collisional interaction rather than to an aggregational behaviour of the probe. The efficient energy migration (Ro = 28 A) of the NBD fluorophore was studied via the fluorescence depolarization upon increase of probe concentration in membranes, and the results are compared with a model where a random distribution of the probes is assumed. A surface location of the chromophore was concluded for the NBD derivative of diacylglycerol, both from the fluorescence parameters and from the study of its fluorescence quenching by spin label probes. Very high lateral diffusion coefficients were obtained for these probes, both from the self-quenching (D = 2-6 x 10(-6) cm2 s-1) and from the spin probe quenching (D = 3.5 x 10(-6) cm2 s-1) studies. A concomitant fluorescence study of the related probe NBD-phosphatidylcholine revealed that its photophysical behaviour is similar to the derivatized diacylglycerol.
Laxative online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8200058&dopt=Abstract lecithin
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