References: Lecithin
Chem Phys Lipids. 1988 Jun;47(2):129-33.
Direct electron spin resonance evidence for alpha-tocopherol-induced phase separation in model membranes.
Severcan F, Cannistraro S.
Dipartimento di Fisica dell'Universita di Perugia, Italy.
The high resolution (narrow linewidth) amphiphilic spin probe perdeutero di-t-butyl nitroxide (PDDTBN) has been used to investigate the effect of alpha-tocopherol on lecithin liposomes. The electron spin resonance (ESR) results obtained as a function both of alpha-tocopherol concentration and of temperature indicate the presence of two different hydrophobic sites for the spin probe molecules. The presence of two distinct phases, one alpha-tocopherol-poor and the other alpha-tocopherol-rich, is suggested in these phospholipid bilayers.
Laxative online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2842078&dopt=Abstract lecithin
vetmed.wsu.edu
A prospective study was performed to determine the relative availability of buspirone and amitriptyline after oral and transdermal routes of administration in 6 adult cats. For topical administration, drugs were compounded in a transdermal organogel containing pluronic and lecithin (PLO). Using a crossover design, each cat received a single dose of amitriptyline (5 mg) and buspirone (2.5 mg) by the transdermal and oral route of administration with at least a 2-week washout interval between drug treatments. Blood samples were obtained at 0, 0.5, 1, 2, 4, 6, 8, 10, and 12 hours after drug administration for determination of plasma drug concentrations. Plasma concentrations of immunoreactive amitriptyline and buspirone were determined using commercial enzyme-linked immunosorbent assay (ELISA) tests. Systemic absorption of amitriptyline and buspirone administered by the transdermal route was poor compared with the oral route of administration. Until supporting pharmacokinetic data are available, veterinarians and cat owners should not rely on the transdermal route of administration for treating cats with amitriptyline or buspirone.
Laxative online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14765730&dopt=Abstract lecithin
Pharm Res. 1995 Jan;12(1):39-48.
Structures of nanoparticles prepared from oil-in-water emulsions.
Sjostrom B, Kaplun A, Talmon Y, Cabane B.
Institute for Surface Chemistry, Stockholm, Sweden.
Hydrophobic substances were dissolved in an organic solvent and emulsified with an aqueous solution at very high shear. Droplets of very small sizes (50-100 nm) were obtained by using surfactants which were combinations of lecithins and bile salts. After emulsification, the organic solvent was removed by evaporation, yielding stable dispersions of solid particles. The sizes, shapes, and structures of the particles were examined through quasi-elastic light scattering, small-angle neutron scattering and cryotransmission electron microscopy. Cholesterol acetate particles stabilized by lecithin and bile salts were found to be platelets of 10-20 nm thickness and 80 nm diameter. Cholesteryl acetate particles stabilized with POE-(20)-sorbitan monolaurate were dense spherical globules of diameter 100 nm. Particles with a composition similar to the endogenously occurring, lipoprotein, LDL, were large spherical globules studded with small vesicles. The subsequent evolution of the cholesteryl acetate dispersion upon aging was examined. There was no transfer of cholesteryl acetate between particles nor to large crystals. However, some aggregation of the particles was observed when the volume fraction of the particles in the aqueous dispersion exceeded 0.05. Thus, the structure of the nanoparticles obtained through deswelling of emulsion droplets changes according to the nature of the emulsifiers and to the composition of the hydrophobic substances which they contain.
Laxative online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7724486&dopt=Abstract lecithin
Buy Rx Online || Hair Million herbal formula for hair loss and hair growth || Hair Million, excellent herbal formula, wards off hair loss and promotes hair growth || Buy Tramadol || Lecithin product online guide ||