References: Lecithin
Riv Neurol. 1989 Jan-Feb;59(1):26-31.
[Preparation, properties and therapeutic potential of cytidine diphosphocholine incorporated into liposomes]
[Article in Italian]
Burlina AP, Galzigna L.
Cytidine diphosphocholine (CDC) was incorporated into unilamellar egg lecithin liposomes with a yield of 23% and subsequently administered to rats by intracardiac injection. Unlike free CDC, 0.2% of which was absorbed by the brain, 21% of the CDC-liposomes was absorbed by the brain, while their relative distribution among brain phospholipids was similar. The changes in blood concentration and brain content of CDC, with and without liposomes, were measured at different times after administration. The CDC-liposome association significantly increased, unlike CDC alone, the levels of dopamine catabolites in the striatum of rats treated with haloperidol (0.15 mg/Kg/die) after 5 days of intravenous administration (20 mg/Kg/die).
Laxative online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2762734&dopt=Abstract lecithin
Akush Ginekol (Sofiia). 1989;28(2):31-5.
[Comparative evaluation of the black foam film method for determining lung surfactant maturity in the newborn infant]
[Article in Bulgarian]
Zhekova N, Lalchev Z.
The present study evaluates a recently introduced method of black foam film (BFF) for determination of lung maturity, adapted for examination of nasopharyngeal aspirate (NFA) in the newborn and as well as to discover its diagnostic value by clinical verification and comparison with the method of total phospholipids (TPL) and with the ratio of lecithin/sphingomyelin (L/S). Comparing the results, obtained by the various methods, it was found that the capability of NFA of the newborn children to form BFF reflected the content of TPL and the ratio of L/S. The good correlation with the clinical state respectively with respiratory function of the examined children indicates the possibility that the method of BFF could be used for postnatal evaluation of lung maturity.
Laxative online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2764247&dopt=Abstract lecithin
isof.cnr.it
Trans unsaturated fatty acids in humans may be originated by two different contributions. The exogenous track is due to dietary supplementation of trans fats and the endogenous path deals with free-radical-catalyzed cis-trans isomerization of fatty acids. Arachidonic acid residue (5c,8c,11c,14c-20:4), which has only two out of the four double bonds deriving from the diet, was used to differentiate the two paths and to assess the importance of a radical reaction. A detailed study on the formation of trans phospholipids catalyzed by the HOCH2CH2S* radical was carried out on L-alpha-phosphatidylcholine from egg lecithin and 1-stearoyl-2-arachidonoyl-L-alpha-phosphatidylcholine (SAPC) in homogeneous solution or in large unilamellar vesicles (LUVET). Thiyl radicals were generated from the corresponding thiol by either gamma-irradiation or UV photolysis, and the reaction course was followed by GC, Ag/TLC, and 13C NMR analyses. The isomerization was found to be independent of cis double bond location (random process) in i-PrOH solution. In the case of vesicles, the supramolecular organization of lipids produced a dramatic change of the isomerization outcome: (i) in egg lecithin, the reactivity of arachidonate moieties is higher than that of oleate and linoleate residues, (ii) in the linoleate residues of egg lecithin, the 9t,12c-18:2 isomer prevailed on the 9c,12t-18:2 isomer (3:1 ratio), and (iii) a regioselective isomerization of SAPC arachidonate residues occurred in the 5 and 8 positions. This effect of "positional preference" indicates that thiyl radicals entering the hydrophobic region of the membrane bilayer start to isomerize poly
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