References: Lecithin
Biochim Biophys Acta. 1992 Oct 5;1110(2):171-7.
Archaebacterial lipid models: highly salt-tolerant membranes from 1,2-diphytanylglycero-3-phosphocholine.
Yamauchi K, Doi K, Kinoshita M, Kii F, Fukuda H.
Department of Bioapplied Chemistry, Osaka City University, Japan.
1,2-Di(3RS,7R,11R-phytanyl)-sn-glycero-3-phosphocholine and its glycerol epimers were synthesized as model lipids of archaebacterial halophiles. These amphiphiles, upon sonication of aqueous suspensions, gave rise to small unilamellar vesicles (SUV) of 300-800 A in diameter and about 80 A in the membrane thickness. The liposomes were very stable for at least a month even in a highly concentrated suspension or 5 M aqueous NaCl. The vesicles could retain Na+ and Cl- ions as well as 5(6)-carboxyfluorescein in the aqueous interior at temperature as high as 70 degrees C. The liposomes of ordinary diester lipids such as 1,2-dipalmitoyl-sn-glycero-3-phosphocholine and egg-yolk lecithin were less stable and more permeable than those of the diphytanyl lipids.
Laxative online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1390846&dopt=Abstract lecithin
Vopr Med Khim. 1994 Jan-Feb;40(1):41-4.
[Characteristics of the lipid composition of atherogenic and anti-atherogenic serum lipoproteins in patients with bronchial asthma]
[Article in Russian]
Lizenko MV, Petrovskii VI, Kotenko TV, Regerand TI.
Complete lipid composition was estimated in both atherogenic lipoproteins of low density (LDL) and in antiatherogenic lipoproteins of high density HDL2 and HDL3 subfractions isolated from blood serum of 25 healthy volunteers and of 40 patients with bronchial asthma; ultracentrifugation, thin-layer chromatography and spectrophotometry were used in experiments. Development of bronchial asthma was accompanied by district impairments in the spectrum of structure containing lipids especially due to decrease in content of lecithin in LDL and HDL2, of phosphatidic acid in LDL and in the HDL fractions; both these lipids are main constituents of the surfactant system in the respiratory tract. Besides, metabolism of cholesterol was also impaired, while cholesterol esters were redistributed between various lipoproteins, thus total cholesterol was increased in LDL and HDL3; however, cholesterol coefficient in the patients maintained within the same limits as compared with that of donors.
Laxative online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8122412&dopt=Abstract lecithin
Eur Biophys J. 2004 Jan 9 [Epub ahead of print]
Location and orientation of Triclosan in phospholipid model membranes.
Guillen J, Bernabeu A, Shapiro S, Villalain J.
Instituto de Biologia Molecular y Celular, Universidad "Miguel Hernandez", 03202, Elche-Alicante, Spain.
Triclosan is a hydrophobic antibacterial agent used in dermatological preparations and oral hygiene products. Although the molecular mechanism of action of this molecule has been attributed to inhibition of fatty acid biosynthesis, earlier work in our laboratories strongly suggested that the antibacterial action of Triclosan is mediated at least partly through its membranotropic effects. In order to assess its location in phospholipid membranes, high-resolution magic-angle spinning natural abundance (13)C NMR of Triclosan embedded within egg yolk lecithin model membranes has been used to obtain (13)C spin-lattice relaxation times for both Triclosan and lecithin carbon atoms in the presence of Gd(3+ )ions. The results indicate that Triclosan is localized in the upper region of the phospholipid membrane, its hydroxyl group residing in the vicinity of the C=O/C2 carbon atoms of the acyl chain of the phospholipid, and the rest of the Triclosan molecule is probably aligned in a nearly perpendicular orientation with respect to the phospholipid molecule. Intercalation of Triclosan into bacterial cell membranes likely compromises the functional integrity of those membranes, thereby accounting for at least some of this compound's antibacterial effects.
Laxative online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14714154&dopt=Abstract lecithin [PubMed - as supplied by publisher]
Lecithin online literature
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