References: Lecithin
J Microencapsul. 1995 Mar-Apr;12(2):165-72.
Thermal analyser and micro FT-IR/DSC system used to determine the protective ability of microencapsulated squid oil.
Lin SY, Hwang LS, Lin CC.
Department of Medical Research, Veterans General Hospital-Taipei, Republic of China.
Squid oil was microencapsulated by spray drying method. Gelatin, sodium caseinate, maltodextrin were contained in spray drying formulation with or without lecithin and microcrystalline cellulose (Avicel). The thermal stability of the unencapsulated and encapsulated squid oils was determined by pressure differential scanning calorimetry (PDSC), Fourier transform infrared (FT-IR) microscopic photometer with DSC system and themogravimetric analysis (TGA). The results indicate that the above analytical apparatus is an easy and reliable method to investigate the samples and that the microcapsule prepared by spray-dried formulation with lecithin as an emulsifier and Avicel as a stabilizer exhibits more stable thermal stability and longer shelf-life.
Laxative online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7629659&dopt=Abstract lecithin
J Pharm Sci. 1995 Apr;84(4):399-403.
Preparation and characterization of fibrinogen-coated, reversibly adhesive, lecithin/cholesterol vesicles.
DeAnglis AP, Retzinger GS.
Department of Pathology, University of Cincinnati Medical Center, OH 45267, USA.
We have developed a method for producing fibrinogen-coated, reversibly adhesive, lecithin/cholesterol vesicles. In this method, fibrinogen, which is acylated in the presence of preformed vesicles, spontaneously incorporates into vesicular membranes. The degree of incorporation is a function of the extent of acylation of the protein. Fibrinogen-coated vesicles aggregate in the presence of thrombin, a consequence of intervesicular fibrin formation. The rate and extent of thrombin-initiated aggregation depend on the fibrinogen surface concentration. Once aggregated, fibrin-coated vesicles can be dissociated by plasmin and by agents that disrupt intervesicular fibrin dimerization such as heparin and the tetrapeptide Gly-Pro-Arg-Pro. Fibrinogen-coated vesicles can be made to bind avidly to the surface of solution phase fibrin matrices and can be incorporated into solution phase fibrin clots. Fibrinogen-coated vesicles also bind to activated platelets. We propose that fibrinogen-coated vesicles will have practical applications as biomimetic hemostatic agents and as vehicles for the fibrin-specific targeting of drugs and other molecules.
Laxative online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7629727&dopt=Abstract lecithin
Ann Med. 1995 Apr;27(2):193-8.
Influence of oral contraceptive use on lipoprotein (a) and other coronary heart disease risk factors.
Porkka KV, Erkkola R, Taimela S, Raitakari OT, Dahlen GH, Viikari JS.
Third Department of Medicine, University of Helsinki, Finland.
We have studied the influence of oral contraceptive use on lipoprotein (a) levels in a cohort of women aged 18, 21 and 24 years (n = 559). Data was available on oral contraceptive formulation and dosage, anthropometric variables, exercise, serum lipoprotein (a), insulin, lipid and apolipoprotein levels. Lipoprotein (a) was determined by radioimmunoassay. Differences were assessed with non-parametric statistical methods. Forty per cent of the study women used oral contraceptives. The use of desogestrel-containing monophasic preparations was associated with lower levels of lipoprotein (a) compared to triphasic/levonorgestrel formulations or to non-users (P = 0.005). This effect was seen only in non-smoking women. Oral contraceptive users had higher levels of serum apolipoprotein B, HDL3-cholesterol, apolipoprotein A-I, triglycerides and systolic blood pressure, and lower serum lecithin:cholesterol acyltransferase activity. Lifestyle factors (smoking, exercise) showed no significant influence on lipoprotein levels. In conclusion, the use of desogestrel-containing oral contraceptives has a marked lowering effect on lipoprotein levels. Prospective studies will be needed to assess the net influence of oral contraceptive use on cardiovascular health.
Laxative online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7632413&dopt=Abstract lecithin
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