References: Lecithin
Comp Biochem Physiol B. 1989;92(4):675-80.
The presence of acyl-CoA: cholesterol acyltransferase in Tetrahymena pyriformis W.
Billheimer JT, Landrey JR, Conner RL.
Cardiovascular Group, E.I. Du Pont de Nemours and Company, Wilmington, DE 19898.
1. The esterification of cholesterol was studied in Tetrahymena pyriformis an organism which does not synthesize sterols nor are sterols required for growth. 2. Microsomes catalyzed the esterification of cholesterol in the presence of oleoyl-CoA but not oleic acid or lecithin. 3. The enzyme has a similar sterol substrate specificity to that of mammalian acyl-CoA: cholesterol acyltransferase (ACAT) and was inhibited by the specific ACAT inhibitor 58-035. 4. The enzyme is constitutive since activity was observed in cells grown in sterol-free medium when cholesterol was added to the in vitro assay.
Laxative online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2498031&dopt=Abstract lecithin
J Pharm Belg. 1993 Sep-Oct;48(5):335-40.
[Synthesis, biological activity and encapsulation of new adrenergic beta-amino alcohols in phospholipid liposomes]
[Article in French]
Imzil L, Elamrani K, Charaf A, Bouzoubaa M, Leclerc G.
Universite Hassan II Ain Chock, Faculte des Sciences, Casablanca, Maroc.
New beta-amino-alcohols were synthesized and showed beta-blocking biological activity. These potential drugs, as well as natrium salicylate, have been entrapped in phospholipid liposomes. Drug-containing liposomes were prepared from egg lecithin and DPPC (Dipalmitoylphosphatidylcholine) by the injection method. Turbidity measurements and dynamic light scattering were used to characterise the liposome and to study their stability during storage. The entrapment efficiency of the drugs in liposomes was correlated to the partition coefficient of the drugs.
Laxative online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7907141&dopt=Abstract lecithin
Braz J Med Biol Res. 1989;22(8):949-57.
Alterations in the fatty acyl composition of plasma cholesteryl esters in Brazilian patients with hepatosplenic schistosomiasis mansoni.
Gillett MP, Sibrian AM, Dimenstein R, Carvalho VC, Goncalves MM, Chaves-Filho M.
Departamento de Bioquimica, Universidade Federal de Pernambuco, Recife, PE, Brasil.
1. The dyslipoproteinemia commonly occurring in the hepatosplenic forms of schistosomiasis mansoni in Brazilian patients is characterized by low plasma levels of cholesteryl esters and of the cholesterol-esterifying enzyme, lecithin:cholesterol acyltransferase (LCATase, EC.2.3.1.43). 2. In the present study, normal healthy individuals and patients suffering from hepatosplenic schistosomiasis mansoni were compared for the fatty acyl compositions of circulating plasma cholesteryl esters and of those formed in vitro by the action of LCATase on a) the endogenous plasma lipoproteins and b) an excess of lipoprotein substrate composed of heat-inactivated plasma. 3. In patient plasma the proportions of saturated and monounsaturated cholesteryl esters were higher and those of diunsaturated and polyunsaturated esters were lower than in the control group. 4. Similar differences were observed between patients and controls in the proportions of the cholesteryl ester subclasses formed in vitro by the action of LCATase on endogenous plasma lipoproteins. 5. Incubation of fresh normal or patient plasma with excess heat-inactivated plasma as substrate for LCATase produced proportions of cholesteryl ester subclasses similar to those formed during incubation of nonheated aliquots of the appropriate substrate plasma. 6. We conclude that the alterations in fatty acyl composition of plasma cholesteryl esters in patients with hepatosplenic schistosomiasis mansoni do not appear to be a direct consequence of the low levels of LCATase activity in patient plasma.
Laxative online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2517406&dopt=Abstract lecithin
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