References: Lecithin
Eur J Pharmacol. 1998 Mar 5;344(2-3):231-9.
Lecithinized superoxide dismutase attenuates phorbol myristate acetate-induced injury in isolated dog lung.
Miyahara T, Shibamoto T, Wang HG, Koizumi T, Honda T, Kubo K, Sekiguchi M, Koyama S.
Department of Physiology, Shinshu University School of Medicine, Matsumoto, Japan.
Lecithinized superoxide dismutase, a lecithin derivative bound to recombinant human CuZn superoxide dismutase, has a higher affinity for cells such as polymorphonuclear leukocytes and endothelial cells than recombinant human CuZn superoxide dismutase has. We determined the protective effects of lecithinized superoxide dismutase on the increased microvascular permeability induced by phorbol myristate acetate (PMA) in isolated dog lungs. Microvascular permeability was assessed by the capillary filtration coefficient (Kf,c) and solvent drag reflection coefficient (sigma(f)). PMA (13.3 microg) increased microvascular permeability, as evidenced by an increase in Kf,c and the small sigma(f) value. Lecithinized superoxide dismutase at both low (4800 U) and high doses (48,000 U) inhibited the PMA-induced increase in Kf,c, but only the high dose of lecithinized superoxide dismutase attenuated the decrease in sigma(f). Recombinant human CuZn superoxide dismutase did not affect the PMA-induced increase in vascular permeability at either a low (4800 U) or a high dose (48,000 U). These findings suggest that lecithinized superoxide dismutase has a protective effect against oxygen radical-induced lung injury in isolated dog lungs.
Laxative online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9600659&dopt=Abstract lecithin
Arteriosclerosis. 1989 Jan-Feb;9(1 Suppl):I164-8.
Studies on inborn errors of metabolism in Norway.
Norum KR.
School of Medicine, University of Oslo, Norway.
Some 50 years ago, Muller described hypercholesterolemia, xanthomas, and coronary heart disease as symptoms of a genetic disorder. In the 1930s, other important discoveries concerning inborn errors of metabolism were made in Norway. Folling described phenylketonuria, and Refsum examined his first patients with heredopathia atactica polyneuritiformis (phytanic acid storage disease). Several other inborn errors of metabolism have been discovered in Norway: familial lecithin-cholesterol acyltransferase deficiency, methylmalonic acidemia, beta-methylcrotonyl-coenzyme A carboxylase deficiency, pyroglutamic aciduria, and N-acetyl aspartic aciduria. Metabolic and biochemical studies in these patients have revealed new and important metabolic pathways. Studies on patients with inborn errors not first described in Norway have also given important information on key enzymes in metabolic pathways. Thus, studies on patients with cerebrotendinous xanthomatosis and those with Zellweger's syndrome have revealed the normal metabolic route for conversion of cholesterol to bile acids. The discoveries and the clinical and biochemical research in former days were mostly good examples of serendipity combined with excellent clinical alertness. In more recent years, several of the discoveries have resulted from systematic biochemical screening of urine, plasma, or other body fluids from patients with unusual clinical syndromes.
Laxative online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2463828&dopt=Abstract lecithin
Bioorg Khim. 1997 Jan;23(1):75-7.
[Acylation of 3beta-(2-hydroxyethoxy)cholest-5-ene in the presence of lecithin:cholesterol acyltransferase from blood plasma]
[Article in Russian]
Maliugin AV, Misharin AIu.
3 beta-(2-Hydroxyethoxy)cholest-5-ene in the composition of the micellar complexes with apolipoprotein A1 and palmitoyloleoylphosphatidylcholine was acylated in the presence of lecithin-cholesterol acyltransferase from human plasma. The initial rate of acylation was 6-8 times lower than the rate of cholesterol acylation under the same conditions. The presence of 3 beta-(2-hydroxyethoxy)cholest-5-ene did not affect the rate of the enzymic acylation of cholesterol.
Laxative online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9139646&dopt=Abstract lecithin
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