laxative



References: Laxative






Pharmacology. 1988;36 Suppl 1:98-103.
Influence of rhein on rat colonic Na+,K+-ATPase and permeability in vitro.

Wanitschke R, Karbach U.

First Medical Clinic, University of Mainz, FRG.

Rhein, an aglucone of a laxative-acting anthraquinone, which induces net secretion in the human jejunum and colon, does not induce net secretion under open circuit current in in vitro conditions but reduces net absorption of electrolytes and water. In the stripped rat descending colon at a concentration of 2.10(-4) mol/l, the Na+, K+-ATPase is almost completely inhibited resulting in a decreased net absorption of electrolytes and water. There are no changes of the diffusional resistance of the paracellular pathway. Results point to a cellular mechanism of rhein by which absorption is inhibited so that physiological cellular secretion dominates. This does not rule out an additional activation of cellular secretion but net secretion can be explained solely by inhibition of absorption without the assumption of any additional secretory mechanism.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2835785&dopt=Abstract constipation laxative



Compr Gerontol [A]. 1987 Sep;1(3):93-6.
Drug consumption in patients with hip fractures compared with controls.

Sernbo I, Hansson A, Johnell O.

Department of Orthopaedics, Malmo General Hospital, Lund University, Sweden.

All drugs in a prospective series of 309 consecutive patients with cervical fractures and 300 with trochanteric fractures were recorded and compared with an age- and sex-matched randomly selected group from the city population files. A greater consumption of drugs was observed in the hip fracture group compared with the control group. Significant differences were observed for men regarding selective beta 2-adrenergic stimulants and xanthines, laxatives, phenothiazines and anti-psychotic drugs, as well as anti-glaucoma drugs. Women with hip fractures had a significantly greater consumption of diuretics, laxatives, insulin, phenothiazines and other antipsychotic drugs.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2898976&dopt=Abstract constipation laxative



Eur J Pharmacol. 1988 Jan 5;145(1):1-5.
Potentiation by phenolphthalein of the responses of guinea-pig ileum and rat stomach strip to PGE2 and other agonists.

Capasso F, Mascolo N, Romano V, Parkinson N, Bennett A.

Department of Experimental Pharmacology, University of Naples, Italy.

Phenolphthalein was examined for its effect on the activity of isolated muscle (guinea-pig ileum and colon, rat stomach), and on the tissue responses to PGE2, histamine and 5-HT. The ileal circular muscle and both muscle layers of the colon were unaffected by phenolphthalein. In contrast, the laxative potentiated the responses of the longitudinal muscle of guinea-pig isolated ileum and the rat stomach strip to the agonists, particularly PGE2. This potentiation was reduced by indomethacin in vivo, but mepyramine or methysergide had little or no effect. Augmentation of muscle activity by phenolphthalein, particularly in the response to PGE2, may contribute to the laxative effect.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3162417&dopt=Abstract constipation laxative



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