laxative



References: Laxative






Dig Dis Sci. 1989 Aug;34(8):1153-62.
A longitudinal survey of self-reported bowel habits in the United States.

Everhart JE, Go VL, Johannes RS, Fitzsimmons SC, Roth HP, White LR.

Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892.

Information concerning bowel habits was gathered from a representative sample of 14,407 United States adults in the first National Health and Nutrition Examination Survey in 1971-1975 and approximately 10 years later among the same individuals. The prevalence of self-reported constipation, diarrhea, infrequent defecation (three or fewer bowel movements per week), and frequent defecation (two or more bowel movements per day) increased with aging. Women were more likely than men (P less than 0.05) to report constipation (20.8% compared to 8.0%) and infrequent defecation (9.1% compared to 3.2%). Blacks were more likely than whites to report infrequent defecation (P less than 0.05). Older respondents reporting constipation were more likely to use laxatives or stool softeners than younger respondents reporting constipation, but they were also less likely to have infrequent defecation. To evaluate factors predictive of impaired bowel function, case definitions were created using information concerning complaint of constipation, laxative use, frequency of defecation, and stool consistency. Female gender, black race, fewer years of education, low physical activity, and symptoms of depression were independent risk factors for impaired bowel function. This study provides national estimates of bowel complaints and their natural history and examines possible risk factors for constipation.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2787735&dopt=Abstract constipation laxative



Pol Tyg Lek. 1989 Jan 23;44(4):89-91.
[Functional megacolon in children]

[Article in Polish]

Romanczuk W.

The author discusses a group of 21 children (15 boys and % girls aged between 4 and 16 years) with diagnosed syndrome of the functional megacolon. Possible causes of the chronic constipation which could lead to the functional megacolon have been analysed. The treatment--preceded by the detailed analysis of anamnesis and laboratory tests (rectoscopy and contrast medium enema)--included: enemas washing out the colon, emollient and laxative agents, fiber-rich diet, and instructions on the proper defecation. Excellent therapeutical results seem to result from the detailed explanation of causes of the functional megacolon. It has enabled to avoid surgical treatment which should be carried out in these cases in which long-term conservative treatment failed.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2798212&dopt=Abstract constipation laxative



J Formos Med Assoc. 1990 Oct;89(10):915-9, 913.
[Drug interaction between digoxin and bisacodyl]

[Article in Chinese]

Wang DJ, Chu KM, Chen JD, Tarn YH, Su DJ.

Department of Internal Medicine, Tri-Service General Hospital, Taipei, Taiwan, R.O.C.

Digoxin is one of the inotropic agents commonly used to improve cardiac performance in patients with congestive heart failure and to control ventricular response in atrial fibrillation and other supraventricular tachycardias. Bisacodyl (dulcolax), a stimulant laxative, is also commonly prescribed to prevent straining at stool or constipation in these patients. Therapeutic monitoring of digoxin is helpful in the evaluation of clinical response and intoxication of digoxin. For the convenience of serum level measurement, digoxin is usually administered at night before sleep to allow ample time for tissue distribution and then blood sampling the next morning. Concomitant use of these drugs may increase the likelihood of drug interaction. Eleven healthy volunteers, aged 22-26, were studied within 35 days accordingly in four phases. The serum digoxin concentration (SDC) in phase 2 (digoxin and bisacodyl together) showed a significant decrease as compared with phase 1 (digoxin alone) (0.58 +/- 0.03 vs. 0.66 +/- 0.03 ng/ml, M +/- SE, p less than 0.05). The percentage of SDC changes was down to -11.7 +/- 5.4%. Phase 4 (digoxin taken 2 hours before bisacodyl) showed an increase in SDC in comparison with phase 3 (digoxin alone) but was not statistically significant (0.65 +/- 0.03 vs. 0.62 +/- 0.03 ng/ml, M +/- SE, p greater than 0.05). The average frequency of diarrhea was 3.5 times in the first day of phase 2 and 2.7 times in the first day of phase 4. We conclude that in volunteers bisacodyl interacts with digoxin resulting in reduction of the SDC. Interference of the absorption is the most likely mechanism.(ABSTRACT TRUNCATED AT 250 WORDS)

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1981783&dopt=Abstract constipation laxative



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