laxative



References: Laxative






Acta Cytol. 1977 Jan-Feb;21(1):158-61.
Colon cytology simplified using enteric coated encapsulated polyurethane foam as a cellular collecting agent. A preliminary report.

Cromarty R.

The advantage of the method lies in the relative ease of obtaining cellular material. The patient requires some instruction but need not be medically supervised. The major disadvantage is in fecal contamination and frequently cell preservation that may not be comparable to that of other cytologic approaches. The success of the test depends upon harvesting mucus. It is essential that the laxative action be as mild as possible and that after the initial clearing of the colon an adequate rest period is allowed to permit adequate mucus regeneration.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=264750&dopt=Abstract constipation laxative



Arzneimittelforschung. 1977;27(12):2411-4.
[Azapropazone plasma levels under simultaneous treatment with an antacid or laxative]

[Article in German]

Faust-Tinnefeldt G, Geissler HE, Mutschler E.

Azapropazone is a non-steroid antirheumatic drug, commonly used in long-term treatment of inflammatory and non-inflammatory rheumatic diseases. Since antacids and laxatives are often taken simultaneously the present study was concerned with the influence of a concomitant treatment with medium doses of dihydroxy-aluminium sodium carbonate, magnesium aluminum silicate, bisacodyl and anthraquinone cathartics on steady-state plasma levels of azapropazone when azapropazone was given as an oral dose 3 times daily to 15 patients. Azapropazone plasma levels were determined 5 h after azapropazone administration by a direct quantitative thin-layer chromatographic method. Azapropazone plasma levels during simultaneous treatment with antacids were 70.3 +/- 14.1 microgram/ml in comparison to 75.4 +/- 16.5 microgram/ml after azapropazone alone (p = 0.10). After the administration of the laxatives a mean plasma concentration of 68.2 +/- 10.1 microgram/ml was obtained, without laxative the average plasma level of azapropazone accounted for 65.1 +/- 8.1 microgram/ml (p greater than 0.05). There were virtually no effects of simultaneous treatment on azapropazone plasma levels. The results suggest that azapropazone can be given together with antacids and laxatives since there is no significant interaction.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=580058&dopt=Abstract constipation laxative



J Urol. 1976 Aug;116(2):153-5.
Intestinal perforation due to fecal impaction after renal transplantation.

Aguilo JJ, Zincke H, Woods JE, Buckingham JM.

Three renal allograft recipients suffered major intestinal complications shortly after the operation. Identification of diverticular disease, adequate preoperative bowel preparation, avoidance of excessive amounts of non-absorbable antacids, early ambulation, and periodic laxatives and stool softeners can prevent these complications. Surgical management includes careful inspection for additional perforations, resection and colostomy, and continuous peritoneal lavage.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=781315&dopt=Abstract constipation laxative



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