laxative



References: Laxative







Afr J Med Med Sci. 1978 Sep;7(3):157-61.
Bowel habit in a Yoruba rural community: preliminary report.

Lewis EA, Kale OO.

The bowel habit of a rural population 80 kilometres outside Ibadan was examined. Based on the pattern of the diet there, 91% of the apparently healthy subjects have daily bowel actions, 60% have two or more motions a day and the stool was soft in 51% of them. There was no alteration in the frequency and consistency of the stool with advancing age. The range of bowel actions was two to three soft motions per day. Recognizable dietary factors producing this pattern include not only the bulky carbohydrate diet but also the vegetables, pepper, fruits and traditional as well as proprietary laxative products commonly taken by these subjects. The implication of the bowel habit on the prevalence of certain gastrointestinal disease on the basis of Burkitt's hypothesis was examined. Measurements of food transit time and stool weights will form the basis of subsequent studies.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=108935&dopt=Abstract constipation laxative



Scand J Plast Reconstr Surg. 1979;13(1):193-4.
Successful use of a bulk laxative to control the diarrhea of tube feeding.

Frank HA, Green LC.

The greatly increased nutritional demands of the severely burned patient frequently require the use of tube feeding for enternal hyperalimentation. At a time when general patient morale is low and motivation needs to be maximally maintained, there is nothing so dispiriting as the distress of a painful perianal region and uncontrollable liquid stools. Attempts to control the diarrhea which frequently accompanies tube feeding by changing the formula or the method of administration or a wide variety of constipating drugs have all met with very limited success. Based on the clinical observation of a noted gastroenterologist (Bockus), we have administered a mucilagenous hydrophilic colloid bulk laxative (Metamucil) to patients on tube feeding formulae. The dosage and frequency are adjusted to individual patient needs, but average 7 g per liter of liquid formula. The results have been dramatic; namely, the virtual elimination of the diarrhea problem in our burn patients on enteral hyperalimentation by gastric tube feeding. Colonic transit time increases. The stools become formed but soft, cohesive but not adhesive. Perianal irritation does not occur. Neither does soilage of wound, dressings, or bed. No rebound constipation or obstructive symptoms have been encountered. We attribute this response to the same water binding mechanism that allows these colloids to prevent chronic constipation. Our patients may be given as much as 5,000 to 6,000 calories of tube feeding per day. Our patients are not distressed by diarrhea. Our nursing staff is relieved of the burden that entails.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=109911&dopt=Abstract constipation laxative



J Toxicol Clin Toxicol. 1990;28(4):433-44.
Clinical course and outcome in class IC antiarrhythmic overdose.

Koppel C, Oberdisse U, Heinemeyer G.

Medical Intensive Care Unit, Universitatsklinikum Rudolf Virchow, Freie Universitat Berlin, FR Germany.

120 cases of class IC antiarrhythmic overdose, including propafenone, flecainide, ajmaline and prajmaline overdose, were evaluated with respect to clinical course, therapy and outcome. Whereas drug overdose in general has an overall mortality of less than 1%, intoxication with antiarrhythmic drugs of class IC was associated with a mean mortality of 22.5%. Nausea, which occurred within the first 30 minutes after ingestion, was the earliest symptom. Spontaneous vomiting probably led to self-detoxication in about half the patients. Cardiac symptoms including bradycardia and, less frequently, tachyrhythmia occurred after about 30 minutes to 2 hours. Therapeutic measures included administration of activated charcoal, gastric lavage and a saline laxative, catecholamines, and in some patients, hypertonic sodium bicarbonate, insertion of a transvenous pacemaker and hemoperfusion. Fatal outcome was mainly due to cardiac conduction disturbances progressing to electromechanical dissociation or asystolia. Resuscitation, which had to be performed in 29 patients, was successful in only two of them. No correlation was found between fatal outcome, the type of antiarrhythmic, and ingested dose. Since a specific treatment is not available and resuscitive procedures including sodium bicarbonate and insertion of a pacemaker are of limited therapeutic value, early diagnosis and primary detoxification are most important for prevention of fatal outcome.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2176700&dopt=Abstract constipation laxative



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