J Natl Cancer Inst. 1982 Sep;69(3):573-6.
Breath methane excretion in patients with unresected colorectal cancer.
Karlin DA, Jones RD, Stroehlein JR, Mastromarino AJ, Potter GD.
The objective of our study was to verify or refute the observation that patients with unresected colorectal cancer are more likely to be breath methane excretors than the general population. Intracolonic heme had no effect on breath methane excretion of 11 normal volunteers given oral hemoglobin. Laxative-enema colonoscopy preparation had a profound effect on the subsequent measurement of breath methane. Three of 4 volunteer methane excretors became nonexcretors, and 2 remained nonexcretors for 21 days and 7 months, respectively. No significant difference was found in the frequency and the amount of breath methane excretion in 55 patients with unresected colorectal cancer and in 99 control subjects. However, 13 patients with unresected descending or sigmoid colon cancers were almost twice as likely to be breath methane excretors as 38 patients with colorectal cancer at other sites.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6955554&dopt=Abstract constipation laxative
Am J Med. 1990 Jun 20;88(6A):24S-26S.
Over-the-counter antidiarrheal medications used for the self-treatment of acute nonspecific diarrhea.
School of Pharmacy, University of North Carolina, Chapel Hill 27599-7360.
Because there are approximately 100 over-the-counter (OTC) products available for self-treatment of acute diarrhea, it is difficult for consumers or even pharmacists and physicians to be sure which products are both safe and effective. Until Congress expanded the authority of the Food and Drug Administration in 1962, manufacturers only had to prove that their products were safe. Unfortunately, a majority of OTC products that are now available were on the market before 1962. To eliminate all noneffective products, the Food and Drug Administration established a three-phase OTC drug review process. The ultimate goal of this process is to ensure that all OTC medications are safe and effective and carry full and informative labeling. In 1975, the Advisory Review Panel on OTC Laxative, Antidiarrheal, Emetic, and Antiemetic Drug Products published its recommendations on which OTC antidiarrheal ingredients were both safe and effective [Antidiarrheal drug products for over-the-counter human use: proposed monograph. Federal Register 1975; 40: 12902-12944]. After consideration of these recommendations, public comment, and presented new evidence, the Food and Drug Administration published its preliminary safe and effective ingredient listing [Antidiarrheal drug products for over-the-counter human use: tentative final monograph. Federal Register 1986; 51 (83): 16138-16149]. At this time, only three ingredients fulfill both requirements: attapulgite, polycarbophil, and loperamide. The Food and Drug Administration's final decision (to be reported in a monograph) is still forthcoming. Upon publication of this monograph, only antidiarrheal products that contain ingredients in this listing will be allowed to be marketed.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2356846&dopt=Abstract constipation laxative
Acta Med Scand Suppl. 1982;668:91-4.
Influence of a psyllium-based fibre preparation on faecal and serum parameters.
Burton R, Manninen V.
A fibre made of psyllium husk was given to 12 elderly patients for 4 months in order to investigate their faecal output and selected serum parameters. The fibre significantly improved bowel function and faecal output confirming its value as a non-irritant, harmless bulk-forming laxative. Serum cholesterol was decreased by 20% while triglycerides remained unchanged. There was a significant reduction in serum calcium after withdrawal of the fibre supplement. There were no significant changes in serum iron, total iron binding capacity, fibrinogen, or in the haematological parameters (ESR, haemoglobin, leucocyte count) attributable to the fibre. The high phytate content of the fibre does not appear to have any clinically significant effect on mineral absorption. It is suggested that dietary fibre (at least psyllium-based fibre preparations) may have significant cholesterol lowering capacity due to the binding of bile-acids in the intestine.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6963098&dopt=Abstract constipation laxative
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