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References: Laxative

Am Rev Respir Dis. 1990 Dec;142(6 Pt 1):1359-66.
Prevalence of occupational asthma and immunologic sensitization to psyllium among health personnel in chronic care hospitals.

Malo JL, Cartier A, L'Archeveque J, Ghezzo H, Lagier F, Trudeau C, Dolovich J.

Department of Chest Medicine, Hopital du Sacre-Coeur, Montreal, Quebec, Canada.

Psyllium is a high molecular weight laxative that can cause occupational asthma among health care workers who prepare this product for chronically ill patients. The prevalence of immunologic sensitization and occupational asthma to psyllium is unknown. We investigated the personnel of four chronic care hospitals, including two where four cases of occupational asthma had been confirmed the year preceding the trial. A questionnaire and skin prick tests with psyllium and various inhalants were administered to 193 of 248 (78%) of the workers who agreed to participate. Seventy-five subjects (39%) had a history of respiratory symptoms in normal life and/or respiratory symptoms and/or rhinoconjunctivitis after handling psyllium. Six (3%) showed skin reactivity to psyllium. Increased specific IgE antibodies were found in 20 of 162 of the sera that were tested (12%). In the second part of the study, a histamine inhalation challenge was performed on 70 of 75 (93%) of the subjects with a history suggestive of asthma and/or occupational asthma and/or skin reactivity to psyllium. Twenty (29%) had significant bronchial hyperresponsiveness. The six subjects with a history suggestive of occupational asthma (n = 3) and/or asthma (n = 6) and/or positive skin test results to psyllium (n = 6) had significant bronchial hyperresponsiveness and increased specific IgE levels. They all underwent specific inhalation challenges with psyllium in the laboratory. Four developed bronchospastic reactions (two immediate and two dual reactions). We conclude that by including the initial four cases reported in the year preceding the initiation of this trial, the prevalence of IgE sensitization to psyllium

Drug Intell Clin Pharm. 1983 Nov;17(11):815-6.
Treatment of bulimia.

Conner CS.

Bulimia (bulimia nervosa; binge eating) is characterized by episodic eating of large amounts of food, followed by self-induced vomiting or laxative abuse. Psychotherapy has been the mainstay of treatment and often has been unsuccessful. The similarity of bulimia to major depression has led to evaluation of antidepressant drugs for treatment of the disease. Imipramine has proven effective in reducing binging episodes, and further evaluation of antidepressants seems warranted. Phenytoin also has been effective in some cases, suggesting that bulimia may be a neurologic disorder analogous to epilepsy. Optimal treatment may be antidepressants combined with a nutrition/psychotherapy program.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6580131&dopt=Abstract constipation laxative

Br J Clin Psychol. 1984 Feb;23 ( Pt 1):45-52.
Women with eating problems: a community survey.

Cooper PJ, Waterman GC, Fairburn CG.

A survey was conducted of the eating habits and attitudes of a sample of young adult women. Each woman was asked whether she considered herself to have an eating problem. The sample comprised 369 attenders at a family planning clinic. Self-report assessment procedures were used, including the Eating Attitudes Test (EAT) and the General Health Questionnaire (GHQ). Eating problems were reported by 20.6 per cent of the sample. Factors which strongly discriminated between those with an eating problem and the remainder were binge eating and a high score on the EAT. Other important factors were laxative use and high levels of psychological morbidity. Self-induced vomiting was only weakly associated with reporting an eating problem, and past and present weight were unrelated to such reports.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6582960&dopt=Abstract constipation laxative

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