laxative



References: Laxative






Tijdschr Gerontol Geriatr. 1984 Aug;15(4):151-4.
[Constipation in the elderly. II. Prevalence and causes of the use of laxatives and experiences with volume expanders and lactulose in nursing home patients]

[Article in Dutch]

Merkus JW.

A study in a nursing home in the Netherlands confirmed findings from previous studies that a high percentage of geriatric patients use laxatives. This applies especially to patients taking antidepressants or hypnotics in combination with other psychotherapeutic agents or suffering from a neurological disease or to those who are rather inactive. Our study shows that it is possible for the large majority of geriatric patients using other laxatives to switch to bulk laxatives. This changing-process requires appropriate instructions and demands close attention. Eventually it will result in the normalisation of the patients' defecation, to the daily relief not only of the patient but also of the nursing staff.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6091300&dopt=Abstract constipation laxative



Ann Gastroenterol Hepatol (Paris). 1984 May-Jun;20(3):113-6.
[Anorectal dyschezia. Megarectum]

[Article in Spanish]

Boix-Ochoa J, Casasa JM, Gil-Vernet JM.

Anorectal dyschezia is due to a defect in the coordination between the forces which try and expel the stool and the relaxation of the anus. There are two types: congenital and acquired. In the first case, there is a distal aganglionic zone; these are in fact cases of Hirschsprung's disease. In the acquired cases, the mesenteric plexuses are normal and the aetiology lies in the painful process which affects the anus. Forced dilatation is the only treatment for anorectal dyschezia and it should replace the use of sphincterotomy. In cases of acquired dyschezia, medical treatment consisting of curing the anal cause of the pain, evacuating the rectum of faecalomas, lubricating the faeces recommending the use of a laxative, is successful in the majority of cases. In cases unresponsive to this treatment, forced dilatation of the anus will help achieve cure. We present 255 cases of anorectal dyschezia: 17 cases were congenital and 238 were acquired. In the first group, good results were obtained with forced dilatation in 14 cases. In the second group, this procedure had to be performed in 23 patients for whom medical treatment was unsuccessful. It resulted in remission of symptoms in 20 cases.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6099082&dopt=Abstract constipation laxative



J Pharm Pharmacol. 1984 Feb;36(2):132-3.
Suppression of laxative action of phenolphthalein by orally-administered indomethacin or aspirin.

Capasso F, Mascolo N, Autore G, Duraccio MR.

Oral administration of phenolphthalein produced a dose-dependent increase of wet faeces excreted by mice. The response to phenolphthalein was reduced by pretreatment with indomethacin, aspirin or polyphloretin phosphate (PPP), but not with benoxaprofen. These findings support the view that the effect of phenolphthalein may be suppressed by PG synthetase inhibitors (indomethacin, aspirin) and by PPP.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6143803&dopt=Abstract constipation laxative



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