laxative



References: Laxative






Zhongguo Zhong Yao Za Zhi. 1993 Apr;18(4):236-9, 256.
[Studies on laxative function of maren soft capsule]

[Article in Chinese]

Guo JH, Jiang ML, Peng ZP, Jin Z, Li Z, Xiong S.

Institute of Chinese Materia Medica, Development of Hunan College of Traditional Chinese Medicine, Changsha.

The experimental results show that the Maren soft capsule can increase the amount and weight of the stool of normal mice and model mice with dry stool, promote the advanced percentage of charcoal powder in the small and large intestines of mice, enhance the movement of the smooth muscle of isolated ileum of guinea pigs under physiological conditions or low temperature, as well as strengthen the intestinal movement in rabbits.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8216793&dopt=Abstract constipation laxative



Dis Colon Rectum. 1993 Nov;36(11):1030-6.
Dyschezia and rectocele--a marriage of convenience? Physiologic evaluation of the rectocele in a group of 52 women complaining of difficulty in evacuation.

Siproudhis L, Dautreme S, Ropert A, Bretagne JF, Heresbach D, Raoul JL, Gosselin M.

Service d'Hepato-Gastroenterologie, CHU Pontchaillou, Rennes, France.

Herniation of the anterior rectal wall into the lumen of the vagina (so called rectocele) may be encountered in patients who complain of constipation and emptying difficulties but it is difficult to ascertain whether this anatomic abnormality is an etiologic factor or a consequence of the dyschezia. PURPOSE: The aim of our study was to assess symptomatic, anatomic, and physiologic features encountered in women with a clearly defined rectocele in order to determine the predisposing factors, symptoms, functional associations, and effects on quantified rectal emptying. METHODS: Clinical, physiologic (manometry), and anatomic (evacuation proctography) assessments were carried out in 26 consecutive women (mean age, 47.6 +/- 12 years) with dyschezia and a large rectocele as evidenced by radiography and compared with a group of 26 consecutive women complaining of dyschezia without a significant rectocele (mean age, 42.6 +/- 14 years). Both groups were similar with respect to mean age, parity, laxative abuse, manual anal evacuation, fecal incontinence, urgency, and weekly stool frequency. RESULTS: Patients having a rectocele differed significantly from those without a rectocele in having frequent endovaginal digitation during defecation (7 vs. 1, P < 0.05), more frequent symptoms of urinary incontinence (14 vs. 3, P < 0.001), and a surgical history of hysterectomy (9 vs. 2, P < 0.05). The rectocele group differed in having a delayed rectal emptying (55.5 +/- 38 vs. 30.3 +/- 23 seconds, P < 0.005), a more frequent incomplete rectal emptying (23 vs. 11, P < 0.0005), and was more often associated with a manometric anismus (16 vs. 6, P < 0.0



Eur J Pharmacol. 1993 Aug 3;239(1-3):241-3.
Conventionalization of germ-free rats reverses the disability of rhein anthrone to induce laxation.

Nijs G, De Witte P, Geboes K, Mertens J, Eyssen H.

Laboratory of Pharmaceutical Biology and Phytopharmacology, Institute of Pharmaceutical Sciences, K.U. Leuven, Belgium.

This study shows that rhein anthrone has no laxative potency in germ-free rats because after intracaecal administration of a dose of 50 mg/kg the large intestine transit exceeded 240 min. The time course of the laxative potency of rhein anthrone injected intracaecally was evaluated after peroral inoculation of germ-free rats with the caecal contents of conventional rats. Large intestine transit was measured at consecutive periods, on days 0, 1, 2, 3 and 5 after peroral inoculation. It appeared that 1 day after peroral inoculation the laxative potency of rhein anthrone was already established (large intestinal transit < 10 min) and laxation remained on the following days (days 2, 3 and 5). We concluded that rhein anthrone is inactive in germ-free rats and acquires laxative potency after peroral inoculation of germ-free rats with caecal contents of conventional rats.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8223901&dopt=Abstract constipation laxative



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