Br J Clin Pharmacol. 1987 Mar;23(3):365-9.
Release of 5-aminosalicylic acid from Pentasa during normal and accelerated intestinal transit time.
Christensen LA, Slot O, Sanchez G, Boserup J, Rasmussen SN, Bondesen S, Hansen SH, Hvidberg EF.
The influence of intestinal transit time on the release of 5-aminosalicylic acid (5-ASA) from a peroral, slow-release preparation (Pentasa) was studied at steady state in seven healthy volunteers. Daily dose was 1500 mg Pentasa, normal transit time (NTT) was 24 h (16-26 h) and accelerated transit time (ATT), caused by a laxative, was 5 h (4-9 h). Median total recovery (24 h, 5-ASA + acetyl-5-ASA) was 87% (61-129%) (NTT) and 81% (56-100%) (ATT), respectively, (P greater than 0.10). The total faecal excretion of 5-ASA (per cent of dose) increased from 16%, (9-21%) (NTT) to 29%, (16-38%) (ATT) (P less than 0.02). Free 5-ASA rose from 12% (4-19%) to 17% (10-25%), the retained part (in granules) from 4% (2-5%) to 12% (4-24%). Urinary excretion decreased correspondingly from 32% (19-59%) to 21% (11-38%), predominantly as Ac-5-ASA (P less than 0.05). Mean plasma Ac-5-ASA concentration decreased from 1.42 micrograms ml-1 to 0.86 microgram ml-1 (P less than 0.05). An almost complete release of 5-ASA from Pentasa takes place during NTT. At ATT conditions about 88% is released, indicating Pentasa to be an acceptable source of 5-ASA in diarrhoeal states.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3567055&dopt=Abstract constipation laxative
Am Rev Respir Dis. 1987 May;135(5):1033-8.
Occupational asthma and IgE sensitization in a pharmaceutical company processing psyllium.
Bardy JD, Malo JL, Seguin P, Ghezzo H, Desjardins J, Dolovich J, Cartier A.
We assessed the prevalence of occupational asthma and IgE sensitization to psyllium in a pharmaceutical company producing psyllium hydrophilic mucilloid, which is used as a laxative. Workers were intermittently exposed, approximately 5 times/yr, for periods of less than 10 days. Of the 140 employees, 130 (93%) were studied before a processing period via a questionnaire spirometry (n = 125), blood sampling (n = 118), and skin prick tests (n = 120) with 7 common inhaled allergens as well as plantain and psyllium. Thirty-nine workers had a history suggestive of occupational asthma. Twenty-three of 120 (19%) showed a skin wheal diameter greater than or equal to 3 mm to psyllium and 31 of 118 (26%) had increased specific IgE antibodies; 39 (32%) workers had at least 1 of these 2 features. Subjects with a questionnaire suggestive of asthma or occupational asthma were further investigated by serial monitoring of peak expiratory flow rates and PC20 methacholine before and during the psyllium processing period. All workers had spirometry repeated during the processing period. Twenty-one subjects who had a PC20 less than or equal to 16 mg/ml (n = 10) and/or decreased their PC20 by a greater than or equal to 3.2-fold difference (n = 4) and/or changed their FEV1 by greater than or equal to 10% (n = 13) during the processing period were referred for inhalation challenges to psyllium in the laboratory. Five of the 18 workers for whom these tests were feasible gave an immediate bronchoconstrictive reaction.(ABSTRACT TRUNCATED AT 250 WORDS)
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3579003&dopt=Abstract constipation laxative
J Occup Med. 1987 Jun;29(6):497-9.
Allergic events among health care workers exposed to psyllium laxatives in the workplace.
An epidemiologic investigation was conducted to ascertain the prevalence of allergic events associated with psyllium in a population of health care workers in long-term care facilities, and to determine if a specific brand of psyllium laxative was associated with the events. Of 743 surveyed health care workers who prepared psyllium laxatives for patients, 136 (18%) reported allergic events. Thirty-four of these employees (5%) reported shortness of breath, wheezing, or hives within 30 minutes after preparing psyllium laxatives. Four hundred thirty-six workers who were exposed to the suspect psyllium laxative were compared with 314 workers exposed to other psyllium laxatives for the occurrence of an adverse event: There was no statistically significant association between exposure to the suspect product and the occurrence of an adverse event. These findings suggest that psyllium laxatives are associated with a spectrum of allergic events ranging from mild to disabling.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3612323&dopt=Abstract constipation laxative
Laxative and constipation online literature ||
Constipation and laxative online literature ||
Constipation and laxative online literature ||
Colon cleansing online literature
DreamPharm: Herbal and Nutritional supplements online ||
Hair Million herbal formula for hair loss and hair growth ||
Hair Million, excellent herbal formula, wards off hair loss and promotes hair growth ||
Buy Tramadol ||