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References: Laxative

Hosp Pharm. 1995 Apr;30(4):292-4.
Pharmaceutical care provides positive outcomes for postpartum patients.

Ptashnick MB.

St. Paul's Hospital Pharmacy, Vancouver, British Columbia, Canada.

This study examined a method for incorporating the philosophy of pharmaceutical care into the care of postpartum women to promote patient independence and satisfaction with hospital care. Patients became active participants in their own care through a bedside medication, self-administration program. Results of a patient survey indicated that 146 of 167 patients responded positively to the benefits of the bedside medication program. A self administered medication program for postpartum women allowed for patient controlled analgesic and laxative use. The availability of medications before symptom onset, and the provision of pertinent information on use of medications, allowed patients the independence to make appropriate decisions for their own care.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10141870&dopt=Abstract constipation laxative

Int J Eat Disord. 1999 Apr;25(3):311-7.
Laxative withdrawal in eating disorders: treatment protocol and 3 to 20-month follow-up.

Colton P, Woodside DB, Kaplan AS.

Department of Psychiatry, Toronto Hospital, Canada.

OBJECTIVE: This article describes a treatment protocol for laxative withdrawal and presents some preliminary information about response to treatment at 3 to 20-month follow-up. METHOD: Patients were contacted 3 to 20 months after admission and evaluated with a shortened form of the Eating Disorders Examination (EDE). RESULTS: Fifty-seven percent of patients were abstinent from laxatives at follow-up and there were significant reductions in laxative-related symptom variables. Abstinence from laxatives was not accompanied by any other changes in eating behavior and was not associated with any pretreatment variables that were assessed. DISCUSSION: It appears to be feasible to withdraw patients from laxatives as an isolated intervention with a reasonably high rate of success.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10191996&dopt=Abstract constipation laxative

J Nutr Sci Vitaminol (Tokyo). 1998 Dec;44(6):787-98.
Transitory laxative threshold of trehalose and lactulose in healthy women.

Oku T, Okazaki M.

Department of Nutrition, Faculty of Medicine, University of Tokyo, Japan.

The transitory laxative threshold of a partially digestible disaccharide, trehalose, and an undigestible disaccharide, lactulose, was estimated by the dose-response relation between the test substance and the prevalence of diarrhea in 20 healthy female subjects. The subjects ingested several indicated amounts of trehalose or lactulose once daily 2 to 3 h after a meal. The intake of the test substance was stopped at the dose level that caused diarrhea or when the dose reached the maximal level. A record of physical conditions, gastrointestinal symptoms, and fecal conditions was made by all subjects before and after each ingestion of the test substance. Half the subjects experienced no diarrhea even with the ingestion of the maximal dose level (60 g) of trehalose in this study, and the ingestion of up to 40 g of lactulose caused diarrhea in 75% of all subjects. Abdominal symptoms such as flatus, distension, and borborygmus appeared at high prevalence with lactulose and trehalose ingestion, and the effect of lactulose was significantly stronger than that of trehalose at the same dose level (p < 0.05). The quantity of trehalose and lactulose that induced diarrhea differed greatly from person to person. The transitory laxative threshold was estimated as 0.65 g/kg body weight for trehalose and 0.26 g/kg body weight for lactulose by using the regression equation between the dose levels of the test substances and the cumulative incidence of diarrhea. These results suggest that it would be quite acceptable to administer trehalose up to 33 g and lactulose up to 13 g in a person weighing 50 kg.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10197310&dopt=Abstract constipation laxative

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