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References: Laxative

Med J Aust. 1988 Apr 4;148(7):325-7, 330-1.
Dieting and slimming practices of South Australian women.

Crawford DA, Worsley A.

Division of Human Nutrition, University of Otago, Dunedin, New Zealand.

A random population survey of 406 Adelaide women who were aged 18 to 86 years, which was conducted in July, 1986, showed that in the previous year 68% of the women had exercised, 38% of the women had dieted, 15% of the women had fasted, 10% of the women had taken slimming tablets, 6% of the women had used diuretic agents and 3% of the women had used laxative agents in order to reduce or to control their weight. At the time of the survey 43% of women (60% of overweight women and 34% of non-overweight women) were attempting to lose weight. The most common reasons for wishing to lose weight were: to feel better (75% of women); to look better (65% of women); and health or medical reasons (33% of women). In addition, a majority of the women were dissatisfied with the shape of their stomach, hips, midriff, waist, thighs and buttocks. The family doctor, books and magazines acted as the major sources of information on dieting and weight control. However, most of the women felt that their doctors did not provide them with enough advice on this topic, and the women were almost unanimous in their criticism of the preoccupation of magazines with slimness. The results suggest that health professionals need to provide women with more advice on safe weight-control strategies and sensible body-weight goals.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3367836&dopt=Abstract constipation laxative

Br J Cancer. 2001 Jan 5;84(1):90-3.
Pluronic F68 block polymer, a very potent suppressor of carcinogenesis in the colon of rats and mice.

Parnaud G, Tache S, Peiffer G, Corpet DE.

Securite des Aliments, INRA, Ecole Nationale Veterinaire de Toulouse, 23 ch. des Capelles, Toulouse, 31076, France.

Polyethylene-glycol (PEG) is a strong inhibitor of colon cancer in rats, and the most potent suppressor of aberrant crypt foci. 9 PEG-like block copolymers were tested in rodents, after an azoxymethane injection. Dietary pluronic F68 led to a 98.6% reduction in the number of aberrant crypt foci in a first rat study (P< 0.0001). Next 3 studies confirmed this pluronic efficacy in rats and mice. This non-toxic laxative seems roughly 5 times more potent than PEG for chemoprevention. Copyright 2001 Cancer Research Campaign.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11139319&dopt=Abstract constipation laxative

Cancer Causes Control. 2000 Dec;11(10):907-14.
Bowel movement, use of laxatives and risk of colorectal adenomatous polyps among women (United States).

Dukas L, Platz EA, Colditz GA, Willet WC, Giovannucci EL.

Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA.

BACKGROUND: Infrequent bowel movements and use of laxatives have been hypothesized to increase risk of colorectal neoplasia. However, the few existing epidemiologic studies in humans have been inconclusive. PURPOSE: To investigate prospectively the associations of bowel movement frequency and laxative use with the occurrence of adenomatous colorectal polyps in women. METHODS: A total of 17,400 women 36-61 years of age, without previous diagnosis of cancer or polyps, responded to a mailed questionnaire in 1982 that assessed bowel movement frequency and use of laxatives and had an endoscopy between 1984 and 1996. Between 1984 and 1996, 906 cases of adenomatous polyps (496 classified as small (< 1 cm), 358 classified as large (> or = 1 cm) and 52 unclassified) were documented. Relative risks (RRs) of adenomas and 95% confidence intervals (CIs) were calculated using logistic regression. RESULTS: After controlling for adenoma risk factors, the multivariate RRs associated with having bowel movements every third day or less compared to once daily were 0.9 (95% CI: 0.7-1.2) for total colorectal adenomas, 1.0 (95% CI: 0.7-1.5) for large adenomas and 1.0 (95% CI: 0.7-1.3) for adenomas of the colon only. The multivariate RRs associated with weekly to daily laxative use compared to never use were 0.9 (95% CI: 0.7-1.1) for total colorectal adenomatous polyps, 1.0 (95% CI: 0.7-1.5) for large adenomas and 0.8 (95% CI: 0.6-1.2) for colon adenomatous polyps only. CONCLUSION: These findings do not support an association between infrequent bowel movement or laxative use and risk of colorectal adenomas.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11142525&dopt=Abstract constipation laxative

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