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References: Laxative






J Natl Cancer Inst. 1991 Jan 16;83(2):105-10.
Systemic toxic effects associated with high-dose verapamil infusion and chemotherapy administration.

Pennock GD, Dalton WS, Roeske WR, Appleton CP, Mosley K, Plezia P, Miller TP, Salmon SE.

Department of Internal Medicine, University of Arizona, Tucson.

Aside from its more conventional uses as a cardiovascular drug, the calcium channel blocker verapamil has recently been added to chemotherapeutic regimens to reduce drug resistance in B-cell and other neoplasms that express the P-glycoprotein. We recently treated patients with continuous-infusion verapamil (0.15 mg/kg per hour to 0.60 mg/kg per hour) over a 5-day period in combination with continuous-infusion vincristine and doxorubicin plus oral dexamethasone. Seventy-one courses involving 35 hospitalized patients were prospectively studied for cardiovascular and other side effects. Cardiovascular side effects were observed most frequently and consisted of first-degree heart block, hypotension, sinus bradycardia, and junctional rhythms. We observed higher degree heart block, but the QRS interval remained narrow and the ventricular escape rate remained relatively normal. Effects on mean arterial pressure, heart rate, and PR interval were both time and dose related. Severe, symptomatic congestive heart failure was rarely observed. The most common noncardiovascular side effects were constipation, peripheral edema, and weight gain. All systemic toxic effects observed were easily treated or disappeared with either temporary or permanent discontinuation of the verapamil infusion or by a decrease in the dose of verapamil. We conclude that the cardiovascular side effects associated with continuous, high-dose intravenous verapamil therapy are significant and dose limiting but are rapidly reversible. Less cardiotoxic chemosensitizers are needed to reverse multidrug resistance in cancer.

Laxative online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1988684&dopt=Abstract constipation laxative colon cleansing



Br J Surg. 1997 Jun;84(6):808-12.
Totally stapled restorative proctocolectomy.

McCourtney JS, Finlay IG.

Department of Coloproctology, Royal Infirmary, Glasgow, UK.

BACKGROUND: Totally stapled restorative proctocolectomy (TSRP) has simplified ileoanal pouch surgery but few reports exist concerning experience with the technique. A retrospective study of operative and functional data in a consecutive series of patients undergoing TSRP was undertaken. METHODS: TSRP with J pouch formation was attempted in 103 patients between 1988 and 1995 (for ulcerative colitis (87 patients), familial adenomatous polyposis coli (nine), slow transit constipation (six) and hereditary non-polyposis colorectal cancer (one). Three technical failures resulted in 100 patients available for assessment. Case notes were reviewed together with functional assessment by clinical interview and/or postal questionnaire. RESULTS: Median operating time was 200 min, intraoperative blood loss 360 ml and hospital stay 12 days. There were no operative deaths. All but five patients (95 per cent) had loop ileostomy formation with subsequent reversal. There were 29 complications, six of which required further surgical intervention. Six pouches were excised and two patients had a temporary defunctioning ileostomy. Five patients were rediagnosed as having Crohn's disease, of whom four underwent subsequent pouch excision. Pouchitis (in the absence of Crohn's disease) occurred in eight patients (8 per cent). In 60 patients with at least 12 months of established function, median day and night stool frequencies were 5 and 1 respectively. Functional evaluation in 49 patients (82 per cent) revealed regular use of antidiarrhoeal medication in 21, urgency in 17, and total continence by day and night in 37 and 35 respectively. Fifty-three patients (88 per cent) were satisfied with the overall long-term outcome. CONCLUSION: TSRP is safe, has simplified a technically difficult operation and gives good long-term functional results.

PM



Int J Colorectal Dis. 1997;12(2):91-4.
Defaecography in patients with irritable bowel syndrome and healthy volunteers.

Awad RA, Martin J, Guevara M, Ramos R, Noguera JL, Camacho S, Santiago R, Ramirez JL, Toriz A.

Experimental Medicine and Motility Unit, Ministry of Health, Mexico City General Hospital, Mexico D.F.

BACKGROUND: In patients with IBS, many symptoms have their origin in the recto-anal segment, with motility changes in the rectum and in the internal anal sphincter, and alterations in rectal sensitivity. However, up to now, it is not known if these clinical and physiological changes are equated with morphological changes in the recto-anal segment. METHODS: Sixteen consecutive patients with IBS (mean age 22, range 18-33 years; 13 females) and 10 healthy volunteers (mean age 34.5, range 19-50 yr.; 6 males) were evaluated prospectively with defaecography. RESULTS: 1) Anorectal angle: No significant differences were observed in the anorectal angle during rest (91.6 +/- 3.5 degrees vs 92.6 +/- 2.5 degrees) and during defaecation (92 +/- 5.5 degrees vs 98.7 +/- 2.6 degrees) between patients with IBS and healthy volunteers. However, patients with IBS were unable to widen the angle during defaecation, remaining the same at rest (91.6 +/- 3.5 degrees) as during defaecation (92 +/- 5.5 degrees). IBS patients with constipation (n = 2) compared to those with normal frequency defaecation (n = 13) showed no significant differences at rest (95 +/- 6 vs 89.8 +/- 4.1 degrees) and during defaecation (100 +/- vs 88.9 +/- 6.4 degrees). Healthy volunteers widened the angle by more than 5 degrees during defaecation. 2) Perineometry: although not significant, patients with IBS had less perineal descent during the simulated defaecation (1.98 +/- 0.37 cm) than healthy subjects (2.1 +/- 0.3 cm). Nevertheless, during squeeze there was significantly less mobility or perineal descent in patients with IBS than in control subjects (0.21 +/- 0.17 vs 0.95 +/- 0.21 cm; P = 0.01). CONCLUSIONS: The findings of thi



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