References: Laxative
South Med J. 1985 Dec;78(12):1414-6.
Bowel cleansing with polyethylene glycol electrolyte lavage solution.
Beck DE, Harford FJ, DiPalma JA, Brady CE 3rd.
We reviewed our experience with an oral gut lavage solution (GoLYTELY), used as a rapid bowel cleansing preparation, and the prospective clinical trials reported in the literature to compare the overall experience with this type of preparation for colonoscopy and colon surgery. Five studies (546 patients) compared GoLYTELY to standard preparations for colonoscopy, while three trials (177 patients) have studied surgical patients. After evaluating patient tolerance, quality of colonic cleansing, and changes in microflora and colonic gas, GoLYTELY was found to be safe, rapid, and effective. It is well tolerated by patients and may become the preferred method of bowel cleansing.
Laxative online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=4071165&dopt=Abstract constipation laxative colon cleansing
Z Gastroenterol. 1979 Dec;17(12):827-33.
[Whole gut irrigation for cleansing the bowel (author's transl)]
[Article in German]
Kiene K, Knieknecht A, Peerenboom H, Wienbeck M.
Whole gut irrigation with an isotonic electrolyte solution is said to be an effective, easily and rapidly performed cleansing preparation for colonoscopy. We studied the effect of this method upon water and electrolyte metabolism and on intestinal transit. 35 patients were prepared for colonoscopy by whole gut irrigation via a gastric or duodenal tube. We observed a weight gain of 1.8 +/- 0.3 kg (mean +/- SD) and an increase in serum sodium and chloride. These changes were almost completely reversible within 24 hours. During the irrigation the intestinal transit time shortened by about 50%. The results demonstrate that whole gut irrigation has only slight side effects, but caution is warranted in patients with disturbed tolerance of sodium and water.
Laxative online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=532244&dopt=Abstract constipation laxative colon cleansing
Gastrointest Radiol. 1977 Oct 25;2(2):125-8.
A comparison of colonoscopy and roentgenography for detecting polypoid lesions of the colon.
Leinicke JL, Dodds WJ, Hogan WJ, Stewart ET.
This study compares the effectiveness of the roentgen and colonoscopic examination of the colon for detecting polypoid lesions. We evaluated the findings in 64 patients with suspected or known polypoid lesions who received the same colon cleansing regimen for both examinations, and were studied by examiners of similar expertise. As in other studies, the endoscopist had the advantage of knowing the roentgen findings, and the colonoscopic findings were often taken to indicate whether or not a lesion was present. In about half the patients, however, a second roentgen examination, repeat colonoscopy, or surgical specimen provided additional information for scoring. For example, a filling defect of the same size and location on two roentgen examinations, but not demonstrated at colonoscopy was scored as a false negative colonoscopic finding. The study results indicate that 54% of small polyps less than or equal to 0.9 cm in size were missed on roentgen examination, whereas no proven misses for lesions of this size were shown for colonoscopy. This absence of colonoscopic false-negative findings for small polyps, however, may be partially explained by a relative insensitivity of the roentgen method. For larger lesions greater than or equal to 1.0 cm in size the miss-rate for the two examinations was similar: 15% for roentgen examination and 12% for colonoscopy. We conclude: (1) Colonoscopy is a more sensitive method than roentgen examination for detecting small polyps of the colon, and (2) Performance of the two examinations may be comparable for demonstrating lesions 1.0 cm or larger in size.
Laxative online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=615812&dopt=Abstract constipation laxative colon cleansing
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