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About Herbs and Nutrition

Echinacea
Ginseng
Ginkgo
Milk thistle
St. John's wort
Saw palmetto
Bay
Bilberry
Black cohosh
Licorice
DHEA
Royal Jelly
Garlic
Ginger
Coenzyme Q10
Lutein
rutin




DreamPharm Products


Triple B Super Vision
Best eye nutritions in one tablet. A visionary product for eyes.


Lutein-6 and Lutein-20
Lutein helps to protect your over-worked eyes from aging and environmental harms.


Triple G Super Health
Majestic trio of garlic, ginger, and grapeseed extract. What could be better?


Double G Super Power
Ginseng and Gingko biloba together, for sound body and sound mind.


Weight Loss herbal formula
Get in shape herbally, and safely.


Natural Wonder Woman
Three best herbs for women's health.


Milk thistle
Silymarin helps to protect your liver, an over-worked organ.


Saw palmetto
A herb that deters prostate enlargement.


DHEA
The hormone of youth and health.


Coenzyme Q10
Strong anti-oxidant and metabolite that also does your heart good.


Ginkgo biloba
A formula for nutrition, energy, strength, and stamina.


Good Dream
Good sleep is the best medicine.


Herbal Breath
Fundamentally clean and healthy herbal breath.


St John's Wort
Old wisdom care for depression.


Royal Jelly
Natural nutrition for energy, beauty, and youthfulness.


Echinacea
The most popular herb for the colds, flu, and boosting immune system.


Bye Mygrain
Herbs for headaches.


MySerena
Anxiety and nervousness are enemies of health and happiness.


Golden Ener-Z
This may help if you feel weak or are suffering from chronic fatigue.


LaxaColon
Clean intestine, colon means a lot for your health and fitness.


Ginkgo biloba
Natural, leaf formula for brain and eye health.


Hair Million
Herbal formula for hair loss. Be hairy herbally.


HeartPeace
Herbal formula for healthy and stable heart.


FeminiCare
Helps address lady's fatigue and weakness.


FeminiMate
To help address lady's feminine health problems.


HemoStream
For healthy blood circulation.


Stomagic
Herbal formula for stomach health.


Via Vita
Lecithin supplement for health.


PeptiTonic
For stomach comfort.


MegaNutrition
Complete vitamin and nutritional supplement.






Melatonin:

A pineal hormone that induces sleep.

"Melatonin induces sleep and helps to restore sleep cycles for those with sleep disorders due to age, time shift, and jet lag."


"Good sleep will make you healthier and age less."


What is Melatonin?



Melatonin (N-acetyl-5-methoxytryptamine) is a derivative of tryptophan, an amino acid, and a hormone produced by the pineal gland located right at the center of the brain, and responsible for biological, circadian rhythm of our body. Melatonin was discovered by Lerner et al. in 1958 from bovine pineal glands in search of the amphibian skin-lighting factor. Later studies have found the presence of melatonin in the pineal and the blood during the dark and absence during the light period leading to the conviction that melatonin is a chemical messenger of diurnal cycles and synchronizer of endogenous rhythms. Melatonin has also been found in the full spectrum of animal kingdom, including unicellular algae, brown algae, and in higher plants. Despite the ubiquity, its role in many species including plants remain unknown.

Production of melatonin is light dependent: pineal gland synthesizes more melatonin at night, and less during daytime or under light illumination, while serotonine (5-hydroxytryptamine, or 5-HT), another brain hormone derived from tryptophan, is produced more during the daytime and less at night. Prolonged night time or reduced exposure to light (for example, due to seasonal change or weather) leads to "SAD" (seasonally affected disorder) or "winder blues", a psychiatric disorder accompanied by depression affecting 25 million individuals in the US alone, may be associated with melatonin over-production. Deficiency of melatonin can lead to insomnia, and Parkinson's disease .

The most important role of melatonin is probably the modulation of sleep-wake cycle. Pineal gland is controlled by a paired cluster of nerve cells located just above the optic chiasm in the hypothalamus, the cells called suprachiasmatic nuclei (SCN) containing the circardian pacemaker. Although the SCN autonomously functions in a cyclical manner (on a 24-hour basis), environmental lighting strongly influences its action through the changes in pineal N-acetyltransferase, the enzyme that converts serotonin to melatonin, thus the production of melatonin. The amount of melatonin synthesis is closely linked to the sleep pattern in mammals.

Melatonin is also an antioxidant, and has shown to exert protective effects against oxidative stresses, suggesting its role as a protectant of cellular aging, especially in the brain. Other evidences suggest roles of melatonin as a protectant of immune system and inhibitor of cancer development. A major consequence of aging is a decreasing number of melatonin-producing cells in the pineal gland, and a decrease in the amount of melatonin secreted by surviving melatonin-producing cells. This phenomenon might be related to a number of degenerative changes associated with aging process, including shortened sleep time.

Pineal gland produces several hormones other than melatonin: small molecules such as epinephrine (adrenaline), norepinephrine (noradrenaline), histamine, inositol, 5-methoxytryptophol, iodinated compounds, pteridines, and taurine; and peptides such as angiotensin I, arginine vasotocin, enkephalins, melanotripins, and lipotropins.

. Usage

Taking 1-6 mg of melatonin orally about 1 hour before desired bedtime is recommended. In order to overcome time shift, larger dose should be taken initially, and reduced dose subsequently.

Taking larger dose has not been found associated with notable adverse health effects.

Taking low dose of melatonin has been shown to lower pressures in the eyes, suggesting that melatonin may be helpful for treating glaucoma, although it has not been scientifically proven.



Links to Melatonin Research Articles


  • J Biol Rhythms 2002 Aug;17(4):377-86 - Extraocular light exposure does not phase shift saliva melatonin rhythms in sleeping subjects.
  • J Biol Rhythms 2002 Aug;17(4):364-76 - Alteration of internal circadian phase relationships after morning versus evening carbohydrate-rich meals in humans.
  • Neuroendocrinol Lett 2002 Jul;23 Suppl 2:52-6 - Light during darkness, melatonin suppression and cancer progression.
  • Neuroendocrinol Lett 2002 Jul;23 Suppl 2:17-22 - Ocular input for human melatonin regulation: relevance to breast cancer.
  • Neuroendocrinol Lett 2002 Jul;23 Suppl 2:9-13 - REVIEW. Potential Biological Consequences of Excessive Light Exposure: Melatonin Suppression, DNA Damage, Cancer and Neurodegenerative Diseases.
  • J Clin Endocrinol Metab 2002 Aug;87(8):3993-6 - Melatonin secretion and increased daytime sleepiness in childhood craniopharyngioma patients.
  • Pineal Res 2002 Sep;33(2):125-6 - Melatonin has antioxidant effects in the brain.
  • J Pineal Res 2002 Sep;33(2):118-124 - Exposure to short days, but not short-term melatonin, enhances humoral immunity of male Syrian hamsters (Mesocricetus auratus).
  • J Pineal Res 2002 Sep;33(2):109-117 - Melatonin related compounds inhibit lipid peroxidation during copper or free radical-induced LDL oxidation.
  • J Pineal Res 2002 Sep;33(2):95-100 - Role of exogenous melatonin in reducing the nephrotoxic effect of daunorubicin and doxorubicin in the rat.
  • J Pineal Res 2002 Sep;33(2):87-94 - Effect of melatonin and nifedipine on some antioxidant enzymes and different energy fuels in the blood and brain of global ischemic rats.
  • J Pineal Res 2002 Sep;33(2):81-6 - Vascular reactivity in diabetic rats: effect of melatonin.
  • J Pineal Res 2002 Sep;33(2):72-80 - Protective effects of melatonin on myocardial ischemia/reperfusion injury in vivo.
  • Clin Neuropharmacol 2002 Jul-Aug;25(4):194-201 - Biologic rhythms and Parkinson's disease: a chronopharmacologic approach to considering fluctuations in function.
  • Pancreas 2002 Aug;25(2):166-9 - In vivo and in situ action of melatonin on insulin secretion and some metabolic implications in the rat.
  • Pol J Pathol 2002;53(2):59-65 - Effect of melatonin and all-trans retinoic acid on the proliferation and induction of the apoptotic pathway in the culture of human breast cancer cell line MCF-7.
  • Life Sci 2002 May 10;70(25):2977-85 - Melatonin prevents oxidative kidney damage in a rat model of thermal injury.
  • Proc Nutr Soc 2002 May;61(2):191-202 - Antioxidant strategies for Alzheimer's disease.
  • Cell Biochem Funct 2002 Sep;20(3):269-72 - Melatonin in the unicellular Tetrahymena pyriformis: effects of different lighting conditions.
  • J Pineal Res 2002 Aug;33(1):20-30 - Melatonin's unique radical scavenging properties - roles of its functional substituents as revealed by a comparison with its structural analogs.
  • J Pineal Res 2002 Aug;33(1):1-7 - Melatonin protects against gastric ulceration and increases the efficacy of ranitidine and omeprazole in reducing gastric damage.
  • Brain Res 2002 Jul 12;943(2):163-173 - Protective effect of melatonin in a chronic experimental model of Parkinson's disease.
  • J Bone Miner Res 2002 Jul;17(7):1219-29 - Melatonin at pharmacologic doses increases bone mass by suppressing resorption through down-regulation of the RANKL-mediated osteoclast formation and activation.
  • Cardiovasc Drugs Ther 2002;16(1):5-6 - Melatonin protects the heart against both ischemia/reperfusion injury and chemotherapeutic drugs.

    Melatonin Links


  • Links to Research on Melatonin
  • melatonin research melatonin benefits melatonin for sleep melatonin antioxidant by Ray Sahelian, MD
  • Melatonin Summary Menu
  • Scientific American: Melatonin Mania
  • The Health Gazette: Melatonin
  • Dave Blask's Melatonin Research
  • Melatonin - what's all the fuss about?
  • Melatonin
  • High Quantity of Melatonin Identified in Cherries
  • Natural Health Consultants: Melatonin
  • Melatonin: What is the Controversy?
  • Findings On Melatonin




    • The information provided at DreamPharm.com is for educational purposes only and is not intended for self-diagnosis nor self-treatment of conditions that should be managed by a qualified health care provider. Unless otherwise indicated, research, ailment and product information have not been evaluated by the US Food and Drug Administration ("FDA").

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