Dream Pharm Mother Nature's Timesless Recipes Lutein

References online: Lutein

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Lutein and Eye Nutrition Center: Home| Lutein and Eye Nutrition Center: What is Lutein ?| Lutein and Eye Nutrition Center: What does Lutein do for us ?| Lutein and Eye Nutrition Center: Are we taking enough lutein ?| Lutein and Eye Nutrition Center: Are there other eye nutritions than Lutein ?| Lutein and Eye Nutrition Center: Research Reports: Role of Carotenoids| Lutein and Eye Nutrition Center: Research Reports: Serum lutein and carotenoid level in response to taking dietary carotenoids| Lutein and Eye Nutrition Center: Research Reports: Lutein and Lung Function| Lutein and Eye Nutrition Center: Research Reports: Lutein and Congestive Heart Failure| Lutein and Eye Nutrition Center: Research Reports: Lutein, Lycopene, and Prostate Cancer| Lutein and Eye Nutrition Center: Research Reports: Lutein, carotenoids, and breast cancer| Lutein and Skin Cancer| Lutein: General Information Page| Lutein and Age-related Macular Degeneration| Lutein improves visual function in age-related cataracts patients| Lutein may be a nutritional factor for protecting lens in age-related cataracts patients| Intakes of antioxidants in coffee, wine, and vegetables are correlated with plasma carotenoids in humans.| Plasma Antioxidant Status, Immunoglobulin G Oxidation and Lipid Peroxidation in Demented Patients: Relevance to Alzheimer Disease and Vascular Dementia.| Photo-oxidative stress in a xanthophyll-deficient mutant of Chlamydomonas.| Application of tristimulus colorimetry to estimate the carotenoids content in ultrafrozen orange juices.| Macular pigment: quantitative analysis on autofluorescence images.| QTL and candidate genes phytoene synthase and zeta-carotene desaturase associated with the accumulation of carotenoids in maize.| Thermal processing of vegetables increases cis isomers of lutein and zeaxanthin.| Serum vitamins and the subsequent risk of bladder cancer.| The relationship between dietary carotenoids and prostate cancer risk in Southeast Chinese men.| Macular pigments: their characteristics and putative role.| The effect of an acute phase response on tissue carotenoid levels of growing chickens (Gallus gallus domesticus).| Resonance Raman measurement of macular carotenoids in retinal, choroidal, and macular dystrophies.| Assessment of carotenoid bioavailability of whole foods using a Caco-2 cell culture model coupled with an in vitro digestion.| Lutein, zeaxanthin, macular pigment, and visual function in adult cystic fibrosis patients.| Serum Carotenoid and Retinol Levels during Childhood Infections.| Chlorophyll, carotenoids and the activity of the xanthophyll cycle.| De-epoxidation of violaxanthin in light-harvesting complex I proteins.| Carotenogenesis during tuber development and storage in potato. epid.unimaas.nt

Results of a randomized controlled trial have suggested a protective effect of selenium against prostate cancer. Few other prospective studies have been conducted to confirm or refute this. The association between prostate cancer and baseline toenail selenium level was evaluated in the Netherlands Cohort Study, conducted among 58,279 men, aged 55-69 years at entry. In September 1986, the cohort members completed a questionnaire on risk factors for cancer and provided toenail clippings for determination of baseline selenium status. After 6.3 years of follow-up, 540 incident prostate carcinoma cases and 1,211 subcohort members with complete toenail selenium data were available for case-cohort analyses. In multivariate survival analysis, an inverse association between toenail selenium level and prostate cancer risk was observed. Incidence rate ratios in increasing selenium quintiles were 1.00 (ref), 1.05, 0.69, 0.75, and 0.69 (95% confidence interval, 0.48-0.99), respectively (P-trend=0.008). This association persisted after exclusion of cases diagnosed during early follow-up. The inverse association was more pronounced in ex-smokers than current smokers, and unclear in never-smokers. Analysis of effect modification by intake of antioxidant vitamins C, E, and the carotenoids alpha-carotene, beta-carotene, beta-cryptoxanthin, lycopene, and lutein/zeaxanthin showed a strong, significant interaction with beta-cryptoxanthin, and to a lesser extent with vitamin C. These results confirm the hypothesis that higher selenium intake may reduce prostate cancer risk. Future research on optimum dose level is needed.

lutein online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14504196&dopt=Abstract lutein



J Urol. 2003 Oct;170(4 Pt 1):1146-50.
Serum vitamins and the subsequent risk of bladder cancer.

Nomura AM, Lee J, Stemmermann GN, Franke AA.

Japan-Hawaii Cancer Study, Kuakini Medical Center, Honolulu, USA.

PURPOSE: We determined whether serum vitamins are inversely related to bladder cancer risk. MATERIALS AND METHODS: A cohort of 9,345 Japanese-American men was examined from 1971 to 1977. At examination a blood specimen was obtained and the serum was frozen. After a surveillance period of more than 20 years 111 tissue confirmed incident cases of bladder cancer were identified. Stored serum and that of 111 age matched controls were tested by high pressure liquid chromatography for certain micronutrients, including lutein, zeaxanthin, anhydrolutein, alpha-cryptoxanthin, beta-cryptoxanthin, lycopene, dihydrolycopene, alpha-carotene, beta-carotene, total carotenoids, retinol, alpha-tocopherol, beta-tocopherol, gamma-tocopherol, delta-tocopherol and total tocopherols. RESULTS: Based on quartiles of serum micronutrient levels the ORs for bladder cancer were determined using the general estimating equations approach. There were statistically significant inverse linear trends in risk for alpha-carotene (p <0.01), beta-carotene (p = 0.03), lutein plus zeaxanthin (p = 0.03), beta-cryptoxanthin (p = 0.04) and total carotenoids (p = 0.02). However, after adjustment for pack-years of cigarette smoking none of the inverse trends remained significant. CONCLUSIONS: These results suggest that cigarette smoking, which is a strong risk factor for bladder cancer, may explain the apparent protective effect of individual and total carotenoids against this common cancer.

lutein online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14501712&dopt=Abstract lutein

jhmi.edu

The carotenoids lutein and zeaxanthin are found in the macula in high concentrations and may play a role in the pathogenesis of age-related macular degeneration (ARMD). Lutein and zeaxanthin may protect the macula and photoreceptor outer segments throughout the retina from oxidative stress and play a role in an antioxidant cascade that safely disarms the energy of reactive oxygen species. Although lutein and zeaxanthin are not essential nutrients, studies are beginning to suggest that they fit the criteria for conditionally essential nutrients. Low plasma lutein and zeaxanthin concentrations or dietary intake are associated with low macular pigment density and increased risk of ARMD. Dietary deprivation of lutein and zeaxanthin in primates causes pathological changes in the macula. Should controlled clinical trials show lutein and/or zeaxanthin supplementation protects against the development or progression of ARMD and other eye diseases, then lutein and zeaxanthin could be considered as conditionally essential nutrients for humans.

lutein online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=13679014&dopt=Abstract lutein



J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Sep 25;795(1):17-23.
Capillary high-performance liquid chromatographic determination of lutein and zeaxanthin in aqueous humor from a single mouse eye.

Karlsen A, Alexander G, Blomhoff R, Gundersen TE.

Institute for Nutrition Research, University of Oslo, N-0316 Oslo, Norway.

To protect the eye from ultraviolet phototoxicity caused by free radicals, ocular components such as the aqueous humor accumulate antioxidants, such as the carotenoids. Lutein and zeaxanthin are the only carotenoids known to be present in the aqueous humor. Due to the small sample volume, pooling of samples from an undesirable large number of animals is often required for sufficient sensitivity and statistically significant differences to be achieved. In this paper we present a rapid, sensitive and robust packed capillary high-performance liquid chromatographic visible detection method for the quantification of lutein and zeaxanthin in the aqueous humor of single mouse eyes.

lutein online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12957165&dopt=Abstract lutein

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