Lutein-6 and
Lutein-20
Lutein helps to protect your over-worked
eyes from aging and environmental harms.
Milk thistle
Silymarin helps to protect your liver, an
over-worked organ.
Saw palmetto
A herb that deters prostate enlargement.
Triple B Super Vision
Best eye nutritions in one tablet.
A visionary product for eyes.
Triple G Super Health
Majestic trio of garlic, ginger, and grapeseed
extract. What could be better?
Double G Super Power
Ginseng and Gingko biloba together, for
sound body and sound mind.
Hair Million
Herbal formula for hair loss. Be hairy herbally.
Good Dream
Good sleep, the best medicine.
Herbal Breath
Clean and healthy herbal breath.
Natural Wonder Woman
Best herbs for PMS and menopause.
Herbs for women's health.
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Biology of Hair Growth
Factors influencing Hair Growth
What regulates hair growth
There are too many factors that affect hair growth to list them all here. Various pages on this site list different groups of factors that modify hair follicle activity. In terms of products naturally produced by the body, the key factors that affect hair growth are hormones and cytokines. Hair follicles have receptors for androgens and estrogens that can each affect hair follicle activity. Other hormones including those derived from the thyroid and the pituitary glands can also have significant effects. In addition, there are other naturally produced chemcials called cytokines that act on cells in a hormone-like manner. Below is a table listing hormones and the more common cytokines and their action on hair follicles.
Endogenous substances that affect hair growth
Substance Site of action Effect on hair growth
Basic fibroblast growth factor (bFGF) Dermal papilla Increase
Platelet-derived growth factor (PDGF) Dermal papilla Increase
Transforming growth factor beta (TGF- beta) Dermal papilla Decrease
Interleukin 1-alpha
(IL-1- alpha) Hair matrix Decrease
Fibroblast growth factor type 5 (FGF5) Hair matrix Decrease
Epidermal growth factor (EGF) Hair matrix Decrease
Keratinocyte growth factor (KGF) Hair matrix Increase
Insulin-like growth factor I (IGF-I) Hair matrix Increase
Substance P Unknown Increase
Parathyroid hormone (PTH) Unknown Decrease
Estrogens Unknown Decrease
What regulates the hair growth (clock) cycle
Although human hair follicles apparently cycle through growth and rest independently of each other there must be a mechanism to promote anagen hair growth and the involution of the hair follicle to a resting stage. Clues to the basics of this mechanism have been known about for many years. Any form of skin damage will force telogen hair follicles in rodents into anagen growth in and around the site of injury. Any damage would induce temporary hair growth. As the injury heals so the hair follicles go back to normal. There is similar evidence that injury in humans will also promote growth and induce anagen if the hair follicles are in telogen. Stimulation can come from cuts, scrapes, heat/chemical burns including sun burn, limited local necrosis, and some forms of skin irritation.
Hair Growth Related Resources
Source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12227482&dopt=Abstract Ref: J Dermatol 2002 Aug;29(8):489-98 - Comparative efficacy of various treatment regimens for androgenetic alopecia in men.
Source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12223968&dopt=Abstract Ref: Ann Dermatol Venereol 2002 May;129(5 Pt 2):837-40 - Indications for micrograft hair transplantation.
Source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12223967&dopt=Abstract Ref: Ann Dermatol Venereol 2002 May;129(5 Pt 2):831-6 - Alopecia areata: update on therapy.
Source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12223960&dopt=Abstract Ref: Ann Dermatol Venereol 2002 May;129(5 Pt 2):787-92 - Hormonal interaction and hair growth.
Source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12223959&dopt=Abstract Ref: Ann Dermatol Venereol 2002 May;129(5 Pt 2):783-6 - Implication of VEGF, steroid hormones and neuropeptides in hair follicle cell responses.
Source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12213548&dopt=Abstract Ref: Exp Gerontol 2002 Aug;37(8-9):981 - Molecular mechanisms of androgenetic alopecia.
Source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12207609&dopt=Abstract Ref: Br J Dermatol 2002 Sep;147(3):598-601 - Follicular and epidermal alterations in patients treated with ZD1839 (Iressa), an inhibitor of the epidermal growth factor receptor.
Source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12204716&dopt=Abstract Ref: Surv Ophthalmol 2002 Aug;47 Suppl 1:S185-202 - Prostaglandin-induced hair growth.
Source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12196747&dopt=Abstract Ref: J Am Acad Dermatol 2002 Sep;47(3):377-85 - A randomized clinical trial of 5% topical minoxidil versus 2% topical minoxidil and placebo in the treatment of androgenetic alopecia in men.
Source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12190949&dopt=Abstract Ref: Exp Dermatol 2002 Aug;11(4):381-5 - Simple and rapid method to isolate and culture follicular papillae from human scalp hair follicles.
Source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12167223&dopt=Abstract Ref: Tissue Eng 2002 Jun;8(3):359-66 - Promoted growth of murine hair follicles through controlled release of basic fibroblast growth factor.
Source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12013184&dopt=Abstract Ref: Biomaterials 2002 Jun;23(11):2367-73 - Promoted growth of murine hair follicles through controlled release of vascular endothelial growth factor.
Source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11918709&dopt=Abstract Ref: J Invest Dermatol 2002 Apr;118(4):631-8 - Targeted expression of human vitamin d receptor in the skin promotes the initiation of the postnatal hair follicle cycle and rescues the alopecia in vitamin D receptor null mice.
Source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11915519&dopt=Abstract Ref: Nippon Yakurigaku Zasshi 2002 Mar;119(3):167-74 - Hair growth effect of minoxidil.
Source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11886493&dopt=Abstract Ref: J Invest Dermatol 2001 Dec;117(6):1342-8 - Steroid sulfatase in the human hair follicle concentrates in the dermal papilla.
Source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11817058&dopt=Abstract Ref: J Vet Intern Med 2001 Nov-Dec;15(6):539-46 - The effects of thyroid hormones on the skin of beagle dogs.
Source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11798194&dopt=Abstract Ref: Biochem Biophys Res Commun 200
What is hair?
Curly Hair
Biology of hair growth and development.
The phenomenon of hair loss.
Methods and treatments for hair loss and baldness.
Drugs and hair transplantation surgery for hair loss and baldness.
Hair loss linked to other health problems
Baldness by choice and fashion
Alopecia info.
Alopecia treatment info.
Alopecia treatment info.
Hair care info.
Hair loss and alopecia research articles: abstracts and source links.
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