skin-care-5.matches: skin care
Long-term results of compression treatment for lymphedema.

Pappas CJ, O'Donnell TF Jr.

Department of Surgery, New England Medical Center Hospitals, Tufts University School of Medicine, Boston, MA.

Although numerous operations have been devised for lymphedema, most surgeons manage this vexing condition by nonsurgical means. Previous studies by us showed that high-pressure (90 to 100 torr) sequential external pneumatic compression (SEP) reduced both limb girth and volume in a lymphedematous extremity. To assess the long-term effects of a program entailing (1) SEP, (2) elastic compression stockings to maintain the post-SEP girth, and (3) daily skin care, we reviewed the long-term courses of 49 patients managed by one surgeon. Limb girths measured at nine levels on the limb were obtained serially in follow-up (mean 25 months) by an independent observer to provide an objective response to therapy. The relative reduction in lymphedematous tissue was determined by the difference between the pretreatment, postacute treatment, and long-term treatment girths at nine points in the limb. In long-term follow-up, 26 of the patients maintained a full response (reduction at > 3 levels), whereas 10 maintained a partial response (reduction at < or = 3 levels). At late follow-up, calf and ankle girths were reduced by an absolute value of 5.37 +/- 1.01 and 4.63 +/- 0.88 cm in the full-response group and 5.43 +/- 1.58 and 3.98 +/- 1.18 cm in the partial-response group over pretreatment measurements. The degree of subcutaneous fibrosis in relationship to the duration of the edema appeared to influence results greatly. The treatment of lymphedema with SEP and compression stockings is associated with long-term maintenance of reduced limb girth in 90% of patients.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1404677&dopt=Abstract skin, skin care, skin care medicine skin-care-5.matches: skin care
Pressure ulcer incidence and severity in a community hospital.

Gosnell DJ, Johannsen J, Ayres M.

In a study of 1320 adult patients admitted to a community hospital, there was a pressure ulcer incidence rate of 8.4%, with 3.2% of pressure ulcers present on admission. Of the 190 ulcers found, 63% (n = 120) were hospital acquired and were less severe than those present on admission. There was an average of 1.6 ulcers per patient; 56.3% (n = 107) were Stage I ulcers and 36.3% (n = 69) were Stage II ulcers. The most frequent sites were coccyx-sacral area, heels, and elbows. Preventive measures used most frequently were turning, special mattresses, and special skin care. After a pressure ulcer developed, the most frequently used treatment measures were special bed or mattress, frequent turning, and special ointments and dressings.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1418594&dopt=Abstract skin, skin care, skin care medicine skin-care-1.matches: skin care
Pomegranate fruit extract modulates UV-B-mediated phosphorylation of mitogen-activated protein kinases and activation of nuclear factor kappa B in normal human epidermal keratinocytes paragraph sign.

Afaq F, Malik A, Syed D, Maes D, Matsui MS, Mukhtar H.

Department of Dermatology, University of Wisconsin, 1300 University Avenue, Madison, WI 53706, USA.

Excessive exposure of solar ultraviolet (UV) radiation, particularly its UV-B component, to humans causes many adverse effects that include erythema, hyperplasia, hyperpigmentation, immunosuppression, photoaging and skin cancer. In recent years, there is increasing use of botanical agents in skin care products. Pomegranate derived from the tree Punica granatum contains anthocyanins (such as delphinidin, cyanidin and pelargonidin) and hydrolyzable tannins (such as punicalin, pedunculagin, punicalagin, gallagic and ellagic acid esters of glucose) and possesses strong antioxidant and anti-inflammatory properties. Recently, we have shown that pomegranate fruit extract (PFE) possesses antitumor promoting effects in a mouse model of chemical carcinogenesis. To begin to establish the effect of PFE for humans in this study, we determined its effect on UV-B-induced adverse effects in normal human epidermal keratinocytes (NHEK). We first assessed the effect of PFE on UV-B-mediated phosphorylation of mitogen-activated protein kinases (MAPK) pathway in NHEK. Immunoblot analysis demonstrated that the treatment of NHEK with PFE (10-40 microg/mL) for 24 h before UV-B (40 mJ/cm(2)) exposure dose dependently inhibited UV-B-mediated phosphorylation of ERKl/2, JNK1/2 and p38 protein. We also observed that PFE (20 microg/mL) inhibited UV-B-mediated phosphorylation of MAPK in a time-dependent manner. Furthermore, in dose- and time-dependent studies, we evaluated the effect of PFE on UV-B-mediated activation of nuclear factor kappa B (NF-kappaB) pathway. Using Western blot analysis, we found that PFE treatment of NHEK resulted in a dose- and time-dependent inhibition of UV-B-mediated degradation and phosphorylation of IkappaBalpha and activation of IKKalpha. Using immunoblot analysis, enzyme-linked immunosorbent assay and electrophoretic mobility shift assay, we found that PFE treatment to NHEK resulted in a dose- and time-dependent inhibition of UV-B-mediated nuclear translocation and phosphorylation of NF-kappaB/p65 at Ser(536). Taken together, our data shows that PFE protects against the adverse effects of UV-B radiation by inhibiting UV-B-induced modulations of NF-kappaB and MAPK pathways and provides a molecular basis for the photochemopreventive effects of PFE.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15493960&dopt=Abstract skin, skin care, skin care medicine skin-care-5.matches: skin care
Market research surveys in the marketing of consumer products.

Kurlberg PA, Blomgren P.

ScandInfo AB, Goteborg, Sweden.

To achieve commercial success, any skin care product having given functional properties will on the consumer market also depend on a high degree of attraction, comfort and effective marketing. To accomplish this, consumer surveys are necessary in the various stages of product development and the marketing process. A brief description of the latter is given and of the various types of related surveys. To illustrate certain product tests, examples are given of the relaunch of HTH in the nordic markets.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1466186&dopt=Abstract skin, skin care, skin care medicine skin-care-5.matches: skin care
Skin care in the space environment.

Czerwinski BS, Toback AC.

Envisioned in the 21st century is the United States Space Program's establishment of a permanent human presence in a space station and a moon colony. Mid-21st century humans will take part in an exploratory trip to Mars from the moon (Collins, 1988; Ride, 1987). Fundamental to achieving these space goals will be human health care management. Skin, the largest human organ, will require care. The purpose of this article is to provide an understanding of skin care in the space environment.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1482626&dopt=Abstract skin, skin care, skin care medicine skin-care-5.matches: skin care
Worldwide strategy for skin health care in a financial strait-jacket.

Ryan TJ.

Department of Dermatology, Slade Hospital, Headington, Oxford, United Kingdom.

In consideration of the year 2000, dermatologists must take up the challenge of "Health for All." This paper draws attention to the scope of dermatology, the nature of its work force, the qualifications that are desirable, and the deficiencies and impediments that characterize dermatologic solutions worldwide. It suggests that the future of dermatology depends on achieving appropriate and essential staffing, technology, drugs, and learning materials, within available financial resources. To achieve this, dermatologists must talk more persuasively to those who govern and some centralization of resources into regional training centers may be desirable. Delegation of skin care to purpose-trained auxiliaries, nurses, or medical assistants is essential if costs are to be contained while enlarging the work force.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1512095&dopt=Abstract skin, skin care, skin care medicine skin-care-1.matches: skin care
Histopathologic improvement with lymphedema management, leogane, haiti.

Wilson SF.

Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

In countries where bancroftian filariasis is endemic, lymphedema of the leg is a public health problem, particularly for women, who are disproportionately affected. We investigated the effect of basic lymphedema management (hygiene, skin care, and lower limb movement and elevation) on the histologic features of lymphedema. A total of 118 skin-punch biopsy specimens were collected from the legs of 91 patients enrolled in a lymphedema treatment clinic in Leogane, Haiti. Follow-up biopsy specimens were collected from 27 patients succeeds, equals12 months later. Keratinocyte hyperproliferation, condensed dermal collagen, and mononuclear perivascular infiltrate increased with lymphedema stage, which suggested progressive chronic inflammation and fibrosis. Follow-up biopsies showed reductions in perivascular mononuclear infiltrate in the superficial dermis (41% decrease in prevalence), perivascular fibrosis in the deep dermis (58% decrease), and periadnexal mononuclear infiltrate (53% decrease). These data suggest that the clinical improvement commonly observed with basic lymphedema management has a histologic basis.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15550203&dopt=Abstract skin, skin care, skin care medicine