Vermox
Morphological changes of larval Echinococcus multilocularis in mice treated with albendazole or mebendazole.

Nakaya K, Oomori Y, Kutsumi H, Nakao M.

Animal Laboratory for Medical Research, Asahikawa Medical College, Hokkaido, Japan. nky48 asahikawa-med.ac.jp

Using DBA/2J mice, tissue homogenates of larval Echinococcus multilocularis were injected into the mesenteric veins to generate the liver infection. Mice were treated with either albendazole or mebendazole for prolonged periods to examine the morphological changes of the metacestode. Albendazole induced disorganization of both laminated and germinal layers and suppressed the maturation of vesicles. Amorphous but loosely laminated PAS-positive material was observed inside the damaged vesicles, although new vesicles slightly developed inside or outside of the damaged ones. Active proliferation of vesicles occurred after treatment with albendazole was terminated. Hydatid cysts were more severely damaged in mice treated with mebendazole and new vesicles did not develop around the damaged ones. Also, hydatid cysts reappeared after treatment with mebendazole was terminated. These results indicate that these drugs do not eliminate larval E. multilocularis in the long-term, but mebendazole has a higher suppressive effect on multivesiculation than albendazole.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9858633&dopt=Abstract mebendazole Vermox



Vermox
Identification of the mebendazole polymorphic form present in raw materials and tablets available in South Africa.

Liebenberg W, Dekker TG, Lotter AP, de Villiers MM.

Research Institute for Industrial Pharmacy, Potchefstroom University, South Africa.

A preformulation study of four different raw materials of mebendazole showed that three samples were polymorph C and the other polymorph A, or a mixture of form A and B. X-ray powder diffractometry and infrared spectroscopy indicated that this powder could be form B, but powder dissolution, for which a much slower dissolution was obtained, suggests polymorph A. Literature prescribes the use of polymorph C pharmaceutically, but generic manufacturers should be aware that forms other than C are still available on the market. The four mebendazole tablets currently available in South Africa were also tested and it was found that all of them contained polymorph C.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9876612&dopt=Abstract mebendazole Vermox



Vermox
Plasma levels of mebendazole in children with hydatid disease.

Toppare MF, Gocmen A, Kiper N.

Turkish Health and Therapy Foundation, Ankara.

The plasma levels of mebendazole in children with hydatid cyst disease were measured with high pressure liquid chromatography. In 24 children who received mebendazole orally in a dose of 50 mg/kg, the mean (SD) level 4 hours later was 25.76(9.81) ng/ml (87.6(33) nanomole/l). This result was similar to those in most adult series. During more prolonged treatment, the plasma level 4 hours after the dose of the drug rose significantly with respect to the initial level (p < 0.05).

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1283675&dopt=Abstract mebendazole Vermox



Vermox
Higher sensitivity of the developing larvae of Angiostrongylus cantonensis than the adult worms to flubendazole and mebendazole.

Maki J, Kanda S.

Department of Parasitology, Kitasato University School of Medicine, Sagamihara, Japan.

Two kinds of benzimidazoles, flubendazole and mebendazole were each administered at 10 mg/kg to rats harbouring the developing larvae of the rat lungworm, Angiostrongylus cantonensis 3 or 10 days post-infection and to those harbouring the adult worms 70 days post-infection. Almost all of the larvae were eliminated from the rats mediated 3 days post-infection. The larvicidal effects of the drugs administered 10 days post-infection were not so high as those 3 days post-infection. However, the growth of larvae in rats medicated 10 days post-infection were significantly inhibited as judged from their length, width and weight except the length of the larvae in rats given mebendazole. An inhibition of their growth was also demonstrated by the observation that no first-stage larvae were released from the rats medicated 10 days post-infection and examined 66 days post-infection at which the first-stage larvae were released from non-medicated rats. On the other hand, when the drugs were administered 70 days post-infection, no effects were seen on the number, body size and weight of recovered worms, and the release of the first-stage larvae. A sound conclusion was drawn that the developing larvae are more sensitive to the drugs than the adult worms.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1308254&dopt=Abstract mebendazole Vermox



Vermox
[A comparison of 3 single-dose plans for mebendazole in the treatment of trichuriasis]

[Article in Spanish]

Ramirez Fernandez E, Miquet Romero L, Finlay C.

Instituto de Medicina Tropical Pedro Kouri.

People infected by Trichuris trichiura were selected in a community by the Kato-Katz technique. The study included a universe of 376 persons, male and female, positive and asymptomatic, monoparasitic and multiparasitic. They were divided in treatment groups with not less than 50 people. Monoparasitic patients were treated with 500, 400 and 300 mg of mebendazole, and multiparasitic patients with 500 and 400 mg of mebendazole. In all the cases the drug was used in single doses and its administration was supervised by the physician. Therapeutical response in monoparasitic and multiparasitic patients is shown. It is suggested to use mebendazole single doses of 300 mg in monoparasitic and of 400 mg in multiparasitic patients with an intensiveness of less than 5,000 h/g, as an alternative for treating asymptomatic populations with T. trichiura.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1344682&dopt=Abstract mebendazole Vermox



Vermox
[The efficacy of Vermox and albendazole in an experimental model of nippostrongylosis in mice]

[Article in Russian]

Rashid VM.

Experiments with the model of Nippostrongylus brasiliensis and white outbred mice showed that vermox and albendazole are highly effective anthelmintics in nippostrongyliasis. The ED50 of albendazole for 7 days invasion (adult worms) is 148.9 times higher than for 4 days (fourth instar larvae) and 25.1 times higher than for 2 days (third instar larvae). The ED90/ED10 ratio for albendazole is 1.4, 4.4, and 12.4 at days 7, 4, and 2, respectively. At the adult stage, susceptibility to anthelmintics (vermox and albendazole) increases with age.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1508076&dopt=Abstract mebendazole Vermox