Vermox
Primary echinococcal disease of the kidney: the case for a more conservative approach.

Perimenis P, Athanasopoulos A, Gyftopoulos K, Barbalias G.

Department of Urology, Patras University Hospital, Rio, Greece. perimenis internet.gr

PURPOSE: To evaluate conservative management of renal echinococcosis in cases with normal renal function and active disease. PATIENTS AND METHODS: From a series of 12 consecutive patients with primary renal echinococcosis, nephrectomy was suggested to 4 patients because of kidney destruction. One patient who denied surgery and 5, in whom serological tests were positive, were given mebendazole for 30 days. 3 patients with no evidence of active disease were not given any medication. RESULTS: The patient who denied nephrectomy and 1 out of 5 with positive serological tests did not respond to mebendazole treatment. The latter underwent a cyst excision. Thus, 4 responders to mebendazole and 3 who were not given any medication, avoided surgery and continue to have negative serological tests for more than 3 years. CONCLUSION: Conservative management and long term follow up are proposed for the non-active or mebendazole-responsive patients. For the non-respondents or the cases with kidney destruction, surgery is the only hope for cure.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11989550&dopt=Abstract mebendazole Vermox



Vermox
Evaluation of mebendazole for the treatment of trichuriasis.

Davison RP.

Trichuris trichiura was found to cause severe refractory clinical illness in 25 child patients admitted to a rural hospital in northeast Queensland over a six-month period. Mebendazole produced significant alleviation of symptoms. Symptomless carrier states in 70 patients admitted to hospital for other complaints were also studied. Thirty-five of these were treated with mebendazole with a notable reduction in worm loads (as measured by Stoll egg counts) when compared with the control group. The effects of three-day and four-day courses of mebendazole on symptomless carriers are compared.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=470773&dopt=Abstract mebendazole Vermox



Vermox
Surgery and postoperative mebendazole in the treatment of hydatid disease.

Ammari FF, Omari AK.

Department of General Surgery, Faculty of Medicine, Jordan University of Science and Technology, PO Box 3030, Irbid 22110, Jordan. ffammari yahoo.com

OBJECTIVE: Surgery was virtually the only curative method for hydatid disease until the early 1970s when studies have shown the safety and effectiveness of benzomidazole compounds for the treatment of hydatid cysts. Our aim is to establish the outcome of chemotherapy in the postoperative period on secondary hydatid cyst. METHODS: Between 1987 to 1996 inclusive, all patients who were diagnosed with hepatic hydatid disease and who underwent surgery and received a post operative course of chemotherapy at Princess Basma Teaching Hospital, Irbid, North Jordan, were retrospectively reviewed with special referral to side effects of chemotherapy and recurrence rate of hydatid disease. RESULTS: There were 78 patients (41 females, 37 males). All age groups were involved with an age range of 8-70 years. The main clinical presentation was upper abdominal discomfort, heaviness and mild pain. Ultrasonography and indirect hemagglutination test diagnosed more than 90% of cases. All patients were operated upon and received a postoperative prophylactic course of mebendazole. We reported a recurrence rate of less than 3%. Excessive loss of hair as a side effect to mebendazole therapy occurred in 2 young female patients. CONCLUSION: The postoperative prophylactic course of mebendazole is reliable, safe and with minor side effects and the recurrence rate of the disease was reduced to the lowest possible levels.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12070583&dopt=Abstract mebendazole Vermox



Vermox
Studies on the diagnosis and treatment of human filariasis in Rhodesia.

Goldsmid JM, Rogers S.

Experiences in Rhodesia with various recovery techniques available for the laboratory diagnosis of infections with Dipetalonema perstans and Wuchereria bancrofti are discussed. A diagnostic laboratory regimen for routine filarial investigations is suggested. Included are preliminary observations on the use of mebendazole (Vermox) for the treatment of D. perstans infections.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=60784&dopt=Abstract mebendazole Vermox



Vermox
In vivo effects of mebendazole and levamisole in the treatment of trichuriasis and ascariasis.

Wagner ED, Rexinger DD.

The anthelmintic drugs mebendazole (Vermox) and levamisole were tested in patients for their possible ovicidal effects on the eggs of Trichuris trichiura and Ascaris lumbricoides. The patients studied were 20 Africans of Sierra Leone, and 11 children of Nassau, Bahamas. Egg counts were made before treatment, and for 5 consecutive days following treatment. Eggs were incubated in 2.5% aqueous potassium dichromate and percentages of larval development were determined. Mebendazole completely inhibited the development of the eggs of T. trichiura by day 3 of the follow-up period. The ovicidal action of mebendazole on the eggs of A. lumbricoides was determined to be 64.8% by day 5 of the follow-up study. Levamisole had little (11.6%) ovicidal action on the eggs of T. trichiura and no ovicidal activity for A. lumbricoides.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=626274&dopt=Abstract mebendazole Vermox



Vermox
Efficacy of mebendazole and albendazole against Trichinella spiralis in mice.

McCracken RO.

Changes in the sensitivity of Trichinella spiralis to anthelmintic treatment during the first 3 days of infection in mice were studied. Oral administration of either mebendazole or albendazole at 6.25 mh/kg 2 hr after exposure to infection eliminated 95-100% of the worms as determined at necropsy on day 7 postinoculation. Beyond the first day of infection the sensitivity of the parasite to benzimidazole therapy was much reduced and an oral dose of 50 mg/kg was only partially but significantly active against the adult worms. Despite decline in drug sensitivity during the enteral phase, gavage administration of either mebendazole or albendazole at 50 mg/kg for 5 consecutive days during the invasive phase of infection significantly reduced (96 and 67%, respectively) the number of larvae subsequently recovered from host musculature on day 45 postinoculation.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=641662&dopt=Abstract mebendazole Vermox