Vermox
The use of mebendazole in the treatment of Taenia saginata taeniasis in an endemic area in the Philippines.

Arambulo PV 3rd, Cabrera BD, Cabrera MG.

The successful treatment of Taenia saginata taeniasis with mebendazole is herein reported. 41 subjects ascertained to have taeniasis based on the history of passage of gravid segments and positivity for Taenia egg were treated with 300 mg mebendazole b.i.d. for 3 days without need for fasting. No side-effects were observed. The drug acts as a taeniacide. The worms were expelled either as degenerated boluses or fragmented segments on the 2nd to the 4th day (Mean: 2.4 days) after the initial dose. 33 (84.6%) of the 41 subjects expelled the worm. A follow-up of all the subjects 2--3 months after treatment revealed that all those who expelled the worm following treatment and 6 of those who did not were negative for both Taenia egg and gravid segment, or a cure rate of 95%.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31782&dopt=Abstract mebendazole Vermox



Vermox
[Behavior of the serum titer after treatment with mebendazole in guinea-pigs infected with trichinella spiralis (author's transl)]

[Article in German]

Zander B, Horchner F.

The behavior of the IFT serum titer in 80 guinea-pigs, experimentally infected with Trichinella spiralis, was tested before and after treatment with mebendazole for 6 months. For 14 consecutive days each animal was drenched with 40 mg mebendazole/kg bw on the 25th, 35th and 45th day after infection. After the 2 weeks therapy, living trichinella larvae were not found in any of the 3 treated groups of guinea-pigs. On the other hand even after 6 months viable larvae were found in the muscular tissue of the control animals. Within the first two months p.i. the titers were rising equally in both treated and untreated animals. Only then did the titer in the treated animals decrease markedly, whereas it fell gradually in the controls. After 6 months both groups were negative in the IFT.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=408642&dopt=Abstract mebendazole Vermox



Vermox
[Efficacy of mebendazole in sheep experimentally invaded with larvae of Haemonchus contortus and Trichostrongylus colubriformis in relation to the results of clinical examination]

[Article in Czech]

Zajicek D, Marova M, Zahradnikova W.

A group of six lambs at the age of two months and of the average weight of 13 kg were invaded with the larvae Haemonchus contortus and Trichostrongylus colubriformis; the course of invasion was compared with that in a group of four control lambs. In regular ten-day intervals, some hematological indices, proteinemia. SGOT and SGPT activities, glucose level, sodium and potassium were studied in blood samples; at the same time egg elimination was observed in excrement samples. The invasion intensity was checked by helminthological dissection of an experimentally invaded lamb 35th day p.i.; 576 H. contortus adults and 398 T. colubriformis adults were determined. Egg number recalculated per 1 g excrements (E.P.G.) amounted to 3072. At that stage, both groups were administered mebendazole at a dose of 10 mg active substance per 1 kg live weight on three successive days. The efficacy of the treatment (IE) was 97.01 to 98.05%. According to the clinical examination the hematocrit level dropped statistically significantly on the ninth day p.i., the other indices under study showed no changes. The drug administration increased temporarily the erythrocyte count and decreased MCV and MCH. Although mebendazole mainly inhibited glucose metabolism in the nematodes, the drug administration did not influence the glucose level of the host's blood serum.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=416548&dopt=Abstract mebendazole Vermox



Vermox
[Chemotherapy of human echinococcosis with mebendazole (Vermox): preliminary clinical results]

[Article in German]

Ammann R, Akovbiantz A, Eckert J.

Two patients with inoperable multiple Echinococcus granulosus infections involving the lungs and the liver (one patient) were treated with the following daily doses of mebendazole (Vermox): 3 days 1000 mg, 3 days 1500 mg, the following 3 months 30-40 mg/kg body weight. One of the patients had been treated before with mebendazole in similar doses for 3 periods of 5-6 weeks each. The patients received the drug as 500 mg tablets divided into 3 daily doses after meals. After termination of treatment a distinct regression of lung cysts was demonstrable in both patients, with the exception of one cyst. The liver cyst in one of the patients had also decreased in size. About 8 months after therapy signs of reactivation of lung cysts were observed in one patient, and a new course of mebendazole treatment was therefore started.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=441721&dopt=Abstract mebendazole Vermox



Vermox
Nippostrongylus brasiliensis infection in the rat: effect of iron and protein deficiency on the anthelmintic efficacy of mebendazole, pyrantel, piperazine, and levamisole.

Duncombe VM, Bolin TD, Davis AE, Fagan MR, Kelly JD.

The benzimidazole anthelmintics mebendazole and fenbendazole have been shown to be much less effective against Nippostrongylus brasiliensis infections in the rat on a combined iron and protein deficient diet. In the present experiments it was shown that the anthelmintic efficacy of mebendazole was significantly impaired in the rat on either an iron deficient or a protein deficient diet. Furthermore, iron and protein deficiency reduced the efficacy of the anthelmintics pyrantel and piperazine but not levamisole. The finding that nutritional deficiencies reduce anthelmintic efficacy may well be relevant to worm eradication programmes in iron deficient and protein calorie malnourished populations.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=447110&dopt=Abstract mebendazole Vermox



Vermox
Effect of mebendazole on the larval development of three Hymenolepidid cestodes.

Evans WS, Gray B, Novak M.

Mebendazole or Telmin (which contains 16.7% mebendazole) markedly retarded the development of Hymenolepis diminuta and H. nana when their intermediate hosts Tribolium confusum were fed on flour mixed with it from day 1 to day 10 p.i. Though retardation also occurred with H. microstoma, the effect of the drug on this parasite was noticeably less pronounced than with the other 2 species of this genus.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=448594&dopt=Abstract mebendazole Vermox