Vermox
The use of mebendazole in the treatment of trichinellosis in man.

Mittermayer T, Spaldonova R.

A description is given of an epidemic of trichinellosis in the districts of Kosice and Roznava, Slovakia. the confirmed cause of the epidemic was the consumption of wild hog meat which had escaped a veterinary meat inspection. The course of infection was apparent in 10 patients, inapparent in 16. Mebendazole in doses from 100-600 mg/day was administered for 6-10 days to 9 patients with a clinically apparent, and to one patient with an inapparent infection. Both the clinical course and results of a biopsy examination suggested that the doses had not been high enough for a positive effect of the treatment. Two years after the acute stage of trichinellosis, we repeated the treatment in one patient using a dose of 100 mg/day of mebendazole for a period of 14 days. An improvement of the clinical picture and results of a biopsy examination supported our assumption that an effective treatment of acute trichinellosis requires high doses of mebendazole.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7274835&dopt=Abstract mebendazole Vermox



Vermox
Comparative efficacy of standard antihookworm drugs against various test nematodes.

Misra A, Visen PK, Katiyar JC.

The chemotherapeutic responses of three test nematodes, Nippostrongylus brasiliensis, Nematospiroides dubius and Ancylostoma ceylanicum to standard antihookworm drugs were assessed in order to select a suitable host-parasite system for the primary screening of potential antihookworm compounds. N. dubius behaved inconsistently and, with some infections, required more drug to achieve 100% clearance. Nippostrongylus brasiliensis was found to be sensitive to thiabendazole, tetramisole and levamisole but the broad spectrum anthelmintic mebendazole was ineffective. A. ceylanicum was very sensitive to mebendazole, sensitive to tetramisole and levamisole and refractory to thiabendazole. In vitro, none of the compounds had any lethal effect against any of the nematodes, except mebendazole against A. ceylanicum. A. ceylanicum does occur in man and its chemotherapeutic reactions are similar to those of target hookworm infections of economic importance. As such, although not equally sensitive to standard anthelmintics, it is recommended for routine primary screening.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7310109&dopt=Abstract mebendazole Vermox



Vermox
[Efficacy of mebendazole on Elaphostrongylus rangiferi in reindeer (author's transl)]

[Article in Swedish]

Rehbinder C, Forssell I, Nordkvist M, von Szokolay P.

Elaphostrongylus rangiferi is a very common parasite in Scandinavian reindeer, causing losses due to cerebral nematodiasis and granulomatous parasitic pneumonias and also causing a discard of parts of the carcass at meat inspection. In limited experiments, the efficacy of mebendazole on E. rangiferi has been tested. It was found that daily treatment during a period of 10 days with 6 mg/kg body weight, given as medicated feed, resulted in a decreased fecal larval count at the 10th day and a total cessation of excretion of larvae at the 43rd day, indicating a good anthelmintic effect of mebendazole on E. rangiferi. Single dose treatment with 40 mg/kg body weight was not adequate against E. rangiferi. This dose level, however, completely eliminated excretion of gastrointestinal parasite eggs, as did the 10 day treatment with 6 mg/kg body weight of mebendazole. This dose is double that of the recommended dose for wild ruminants and the need of higher dose is discussed to be due to the dominance of older females of the flock, giving less access to the food for the low-ranked animals. Long-time treatment of reindeer, comparable to the method used, is possible during periods of supplementary feeding during spring-time and then not interfering with the normal management. Deworming will then also intervene with the peak of larvae excretion. Thus it seems possible to considerably decrease the number of larvae on the pastures.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7312589&dopt=Abstract mebendazole Vermox



Vermox
Levamisole compared to mebendazole in the treatment of Ancylostoma duodenale in Egypt.

Kilpatrick ME, Trabolsi B, Farid Z.

Ancylostoma duodenale in 74 patients and Ascaris lumbricoides in 41 were treated with a single 150 mg dose of levamisole, a single 300 mg dose of mebendazole or the standard three-day regimen of 200 mg mebendazole daily. Levamisole cured all of the 25 hookworm patients and all of the seven Ascaris carriers to whom it was given and is recommended as the drug of choice in Egypt.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7324135&dopt=Abstract mebendazole Vermox



Vermox
Clinical toxicosis and erythrocyte cholinesterase inhibition of trichlorfon combined with mebendazole in horses.

Gingerich DA, Mia AS.

Thirty adult horses were used to compare the toxicity and cholinesterase (ChE) inhibition of various dosages of a combination anthelmintic, trichlorfon + mebendazole. Single oral doses of up to 5 times the effective dosage (39.7 mg of trichlorfon and 8.8 mg of mebendazole/kg of body weight) did not result in deaths. Horses given a placebo and horses treated at the recommended dosage rate showed few or no side effects, whereas horses given higher dosages showed dosage-related increases in the severity of clinical signs of organophosphate toxicosis. Dosage-related inhibition of erythrocyte ChE activity was also detected. A 2nd treatment of some of the horses at the recommended dosage 35 days after the initial treatment resulted in minimal or no side effects, despite the fact that erythrocyte ChE activity was still depressed before the repeat treatment. Changes indicating organ toxicosis were not detected in any of the clinical pathologic determinations in any of the dosage groups.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7325477&dopt=Abstract mebendazole Vermox



Vermox
Mebendazole therapy of parenteral trichinellosis.

McCracken RO, Taylor DD.

Mebendazole was highly effective against the helminth parasite Trichinella spiralis in mice subjected to a 3-day course of treatment during the invasive and encystment phases of experimental trichinellosis. When treatment began either 2 or 4 weeks after the mice were inoculated with parasites, the number of larvae developing in the host musculature was greatly reduced by twice-daily oral administration of 3.125, 6.25, or 12.5 milligrams of mebendazole per kilogram of body weight.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7355285&dopt=Abstract mebendazole Vermox