Vermox
[Treatment of hepatic and pulmonary echinococcosis with mebendazole (Vermox)]

[Article in Bulgarian]

Todorov T, Vutova K, Zografski B, Petkov D, Mechkov G.

The therapeutic efficacy of Mebendazole (Vermox) was studied in 13 patients: 8 with liver and 5 with pulmonary echinococcosis. The drug was given in a dose of 50-70 mg/kg body mass. Good therapeutic effect was found in 4 patients (2 with liver nad 2 with pulmonary echinococcosis), partial therapeutic efficiency was registered also in 4 patients (2 with liver and 2 with pulmonary echinococcosis) and failure in 5 patients. The drug was more effective in pulmonary echinococcosis, in younger and smaller cysts than in older cysts with thick walls and presence of filial cysts. The efficacy of the treatment is related to the drug plasma concentration but the results depend on the cysts condition, too. The careful examination of the patients--X-ray, ultrasonography and computer tomography--before, during and after the treatment ensures objective evaluation of the treatment results.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3439155&dopt=Abstract mebendazole Vermox



Vermox
Cystic hydatid disease in Auckland, New Zealand, 1967-1982.

Isaacs RD, Beeching NJ, Ellis-Pegler RB.

Department of Medicine, Auckland Hospital, New Zealand.

The development of anthelmintic chemotherapy has provoked re-evaluation of the management of hydatid disease. We reviewed the case records of 74 patients with 93 episodes admitted to hospitals in Auckland, New Zealand, between 1967 and 1982. Median stay was 29 d (range 1-172). 46 (62%) of the patients were male: 34 (45%) were European and 38 (51%) Maori. The median age was 39 years (range 14-85). The majority of patients presented with symptoms and signs related to local effects of the cyst. 57 (77%) patients had at least one operation and while 34 (60%) had a major surgical complication, only 3 died. At follow-up in 1984, 38 (67%) of the surgical patients and 10 of the 17 (65%) who were not operated on were alive. 9 mebendazole recipients were evaluated: 5 (55%) responded symptomatically, but only one was cured by mebendazole alone. One stopped mebendazole because of side-effects. 2 patients took albendazole: one was cured and one had a symptomatic response. Thus surgery is not always needed. The role of chemotherapy requires further evaluation.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3449998&dopt=Abstract mebendazole Vermox



Vermox
A comparison of the effects of albendazole, its sulphone metabolite, and mebendazole on the viability of protoscoleces of Echinococcus granulosus in an in vitro culture system.

Morris DL, Chinnery JB, Ubhi C.

Department of Surgery, University Hospital, Nottingham, UK.

The effects of albendazole, its sulphone metabolite and mebendazole on the viability of Echinococcus granulosus protoscoleces in vitro were investigated. Significant reductions in viability occurred in cultures treated with albendazole parent compound at 100 micrograms/litre, but lower concentrations were ineffective. The sulphone metabolite of albendazole had no significant effect at concentrations of 50 and 100 micrograms/litre over periods of up to 71 days. Mebendazole induced significant reductions in viability at 100 micrograms/litre.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3450001&dopt=Abstract mebendazole Vermox



Vermox
The use of mebendazole in the treatment of filariases due to Loa loa and Mansonella perstans.

Van Hoegaerden M, Ivanoff B, Flocard F, Salle A, Chabaud B.

International Centre for Medical Research, Franceville, Gabon.

Patients harbouring Loa loa and/or Mansonella perstans infections, or presenting typical filarial symptomatology, were treated with mebendazole, a drug shown to be efficient in other parasitoses. Of the patients who took the drug during 21 days and provided regular blood samples, 84% showed a significant decrease in their L. loa microfilaraemia and 100% in their M. perstans microfilaraemia, with a concomitant improvement in the clinical manifestations and no side reaction to drug administration. Additionally, the long-lasting effect of the drug (up to day 200 in some cases) may suggest a positive action on the adult worm. Mebendazole may consequently be regarded as a safer alternative to diethylcarbamazine for the treatment of these two parasitoses.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3478004&dopt=Abstract mebendazole Vermox



Vermox
In vivo efficacy of mebendazole in containment of larval cyst mass in early stages of hydatid disease due to Echinococcus granulosus.

Wangoo A, Ganguly NK, Mahajan RC.

Department of Parasitology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

The role of mebendazole in treatment of hydatid disease was investigated in a mouse model of human Echinococcus granulosus infection. Each animal received 2000 protoscoleces by intraperitoneal injection. Mebendazole, 50 mg/kg or 200 mg/kg body weight daily for 21 d, was given to 3 groups of animals 2, 4 and 6 months after infection. Significant decreases in numbers of cysts were seen in groups given the drug 2 and 4 months after infection, compared to the group given drug 6 months after infection. 200 mg/kg body weight was more effective in decreasing cyst numbers than 50 mg/kg.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3503417&dopt=Abstract mebendazole Vermox



Vermox
Comparative efficacies of ivermectin, febantel, fenbendazole, and mebendazole against helminth parasites of gray foxes.

Blagburn BL, Swango LJ, Hendrix CM, Lindsay DS.

Department of Pathology, College of Veterinary Medicine, Auburn University, AL 36849-3501.

Anthelmintic efficacies of ivermectin, febantel, fenbendazole, and mebendazole were compared in 45 adult gray foxes (Urocyon cinereoargenteus) naturally infected with helminth parasites. Fecal specimens were examined one week before treatment and one week and 3 weeks after treatment with each anthelmintic, using a sucrose flotation technique. Compared with pretreatment, fewer foxes in all groups were infected with helminths one week and 3 weeks after treatment. Ivermectin, febantel, and fenbendazole more effectively eliminated helminths than did mebendazole. Parasites found were Ancylostoma sp, Capillaria aerophila, and Aelurostrongylus abstrusus and/or Filaroides osleri.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3505933&dopt=Abstract mebendazole Vermox