Vermox
[Morphological changes in the mucosa of the stomach and the small intestine of rats under the action of mebendazole]

[Article in Russian]

Blagov NA, Miagkova MA, Firsov VN, Zhuravleva TB, Petrova IV.

The effect of mebendazole on the gastric and intestinal mucosa was studied in 52 intact white rats. It was shown that the drug caused a significant damage to the mucosa, especially of goblet cells of villi and crypts and interfere with the mucoid secretion. The alterations after mebendazole administration were more severe than those caused by naphthamon. On the 13-15th day after the treatment the complete restoration of the damage was not seen.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1758363&dopt=Abstract mebendazole Vermox



Vermox
[A comparative study of the efficacy of Vermox, albendazole and medamine in an experimental model of trichocephaliasis in mice]

[Article in Russian]

Rashid VM.

A comparison of the efficacy of albendazole, medamine, and Vermox using an experimental model of Trichocephalus muris in DBA-2 mice showed that Vermox was most effective at all stages of the parasite development. The therapeutic activity of albendazole and medamine depends on daily dose, its dividing through the day and the duration of the treatment. At larval stages of T. muris complete recovery might be achieved using a daily dose of 25 mg/kg for albendazole and 150 mg/kg for medamine, but at the adult stage the doses of the drugs should be 3-4 times higher to achieve 100% effect. The resistance of T. muris to the drugs especially increases at the beginning of egg production.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1758364&dopt=Abstract mebendazole Vermox



Vermox
Investigations on the biotransformation of mebendazole using an isolated perfused rat gut system.

Gottmanns H, Kroker R, Ungemach FR.

Bundesgesundheitsamt, Berlin, Germany.

1. The intestinal metabolism of the benzimidazole, mebendazole (MEB), has been investigated using isolated perfused jejunal segments of rats. Significant absorption and intestinal metabolism of the substance was observed. 2. The metabolites, the reduced alpha-hydroxy-analogue, its glucuronide, and the decarbamoylated 2-amino-analogue, were transported into the resorbate collected at the serosal side or were resecreted into the gut lumen. 3. The intestinal decarbamoylation of mebendazole increased up to 20-fold after pretreatment with 3-methylcholanthrene (MC), and complete re-secretion of this metabolite into the gut lumen led to a total loss of the absorption of mebendazole and metabolites across the gut wall. 4. The results indicate the ability of the gut to metabolize mebendazole by phase I and II reactions. 5. An almost complete loss of bioavailability after induction of the gut enzyme system by MC was observed.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1763517&dopt=Abstract mebendazole Vermox



Vermox
[Experience with enterobiasis control measures in the preschool institutions of Lithuania]

[Article in Russian]

Mazhilene OK, Morkunene MA, Kandzizhauskene VP.

The efficacy of treatment and hygienic antienterobiasis measures have been studied in organized groups of preschool children in the Trakay district of Lithuania. Daily washing of all the children and treatment of the invaded children with Vermox once a year proved effective for the prevention of enterobiasis transmission.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1770892&dopt=Abstract mebendazole Vermox



Vermox
Efficacy of methyl 5(6)-(alpha-hydroxyphenylmethyl) benzimidazole-2-carbamate, a metabolite of mebendazole, against developing forms of experimental helminth parasites.

Gupta S, Srivastava JK, Jain MK, Katiyar JC, Singh J, Bhakuni DS.

Division of Parasitology, Central Drug Research Institute, Lucknow, India.

Methyl 5(6)-(alpha-hydroxyphenylmethyl) benzimidazole-2- carbamate, a metabolite of mebendazole, was evaluated against metamorphic forms of Ancylostoma ceylanicum in hamsters, Nippostrongylus brasiliensis in rats and cysticercoids of Hymenolepis nana in grain beetles. The test compound offered better action than mebendazole except against H. nana cysticercoids where the activity of the compound and mebendazole was comparable, but was inferior to the standard cestodicidal drug, praziquantel. The results suggest that the action was better by ip route compared to per os route of drug administration.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1794854&dopt=Abstract mebendazole Vermox



Vermox
Improvement of dissolution and bioavailability for mebendazole, an agent for human echinococcosis, by preparing solid dispersion with polyethylene glycol.

Chiba Y, Kohri N, Iseki K, Miyazaki K.

Department of Pharmacy, Hokkaido University Hospital, School of Medicine, Hokkaido Univerisity, Sapporo, Japan.

The solid dispersion of mebendazole was prepared with polyethylene glycol (PEG) to enhance the dissolution rate of mebendazole, an agent for the chemotherapy of human echinococcosis. The dissolution rate of the solid dispersion increased compared with the physical mixture, and also increased with the incorporation of an increasing amount of PEG-6000. An extensive improvement of the dissolution rate was observed when the ratio of the solid dispersion of mebendazole to PEG-6000 was more than 1: 2. Furthermore, greater bioavailability in rabbits was obtained after oral administration of the solid dispersion compared with the physical mixture.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1797442&dopt=Abstract mebendazole Vermox