Motion sickness susceptibility and related behavioral characteristics in men and women.

Lentz JM, Collins WE.

The incidence of motion sickness in a large (N = 3,618) college population was determined by means of a questionnaire. The test-retest reliability coefficient (0.84) suggested that the motion sickness questionnaire (MSQ) for this particular population yields highly consistent information. Significantly greater proportions of men than women had low susceptibility scores and, conversely, significantly greater proportions of women had high susceptibility scores. The relationships between motion sickness susceptibility scores and several behavioral characteristics in men and women were also investigated. Specifically, comparisons of MSQ scores were made with other self-assessments, age changes, motion experiences, familial susceptibility, use of motion sickness medication, muscular coordination, willingness to participate in motion experiments, flying experience, phobias, visual motion effects, and use of alcohol.

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Some psychological correlates of motion sickness susceptibility.

Collins WE, Lentz JM.

Four groups of 37 subjects each (highly susceptible men, highly susceptible women, nonsusceptible men, and nonsusceptible women) were obtained from a population of 2,432 college students ranging in age from 18 to 39 years. Susceptibility to motion sickness was determined by scores on a motion sickness questionnaire (MSQ); only individuals with extreme scores were considered for inclusion in the experimental groups. The following tests were administered: Floor Ataxia Test Battery, State-Trait Anxiety Inventory, Menstrual Distress Questionnaire, Cornell Medical Index, Cornell Work Form, Eysenck Personality Inventory, Rotter Internal-External Locus of Control Scale, and the 16 Personality Factors test. Each subject was tested on at least three, but not more than six, of the eight tests. Significant sex differences were obtained on the ataxia battery and the Cornell Medical Index. Susceptible subjects did not differ significantly from nonsusceptibles on the ataxia battery but did differ significantly on all personality tests except the Menstrual Distress Questionnaire (administered only to women) and the Rotter Scale. The generally consistent and significant patterns of results from the psychological tests probably reflect the selection factors used in defining the subject groups; certain personality characteristics are associated with a high degree of susceptibility to motion sickness.

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Motion sickness and otolith sensitivity: a pilot study of habituation to linear acceleration.

Potvin AR, Sadoff M, Billingham J.

Astronauts, particularly in Skylab flights, experienced varying degrees of motion sickness lasting 3-5 d. One possible mechanism for this motion sickness adaptation is believed to be a reduction in otolith sensitivity with an attendant reduction in sensory conflict. In an attempt to determine if this hypothesis is valid, a ground-based pilot study was conducted on a vertical linear accelerator. The extent of habituation to accelerations which initially produced motion sickness was evaluated, along with the possible value of habituation training to minimize the space motion sickness problem. Results showed that habituation occurred for 6 of the 8 subjects tested. However, in tests designed to measure dynamic and static otolith function, no significant differences between pre- and post-habituation tests were observed. Cross habituation effects to a standard Coriolis acceleration test were not significant. It is unlikely that ground-based pre-habituation to linear accelerations of the type examined would alter susceptibility to space motion sickness.

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Nystagmus, turning sensations, and illusory movement in motion sickness susceptibility.

Lentz JM.

The relationships of motion sickness susceptibility to nystagmic eye movements, sensations of turning, and duration of the spiral aftereffect were determined with 48 subjects separated into groups on the basis of sex and extremes of motion sickness susceptibility. When subjective alertness levels were controlled, there was no enhancement of elicited nystagmus nor turning sensations in susceptible individuals. However, spiral aftereffect durations were significantly longer in susceptible individuals than in nonsusceptible individuals. The results are interpreted as favoring Graybiel's model of the structural elements in motion sickness.

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Nausogenic properties of various dynamic and static force environments.

von Baumgarten RJ, Vogel H, Kass JR.

Department of Physiology, University of Mainz, FRG.

Motion sickness can occur when an accelerating force acting on the human body repeatedly changes amplitude and direction or both. It also can occur without any motion after transfer into a constant force field significantly different from Earth-gravity. Dynamic and static causes of motion sickness can be distinguished accordingly. Space sickness, too, has dynamic as well as static aspects. Dynamic space sickness might depend on increased bilateral differential sensitivity of the peripheral and central vestibular apparatus, whereas static space sickness may be caused by erroneous compensation of bilaterial asymmetries of the otolith-system in the microgravity environment. Experiments in airplanes, cars and on a vestibular sled have shown that the susceptibility to motion sickness is highest for changes of acceleration in the negative X-axis (as compared to the other axes) of the body. During reciprocating linear accelerations on the vestibular sled, standstill periods of movement and the direction of movement cannot correctly be indicated, because the peripheral vestibular apparatus lacks true motion detectors.

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Coping with space motion sickness in Spacelab missions.

Graybiel A.

Naval Aerospace Medical Research Laboratory, Pensacola, FL 32508, USA.

A substantial number of persons, around 75%, making their first transition into orbital flight will need to adapt to this unique environment. The two most powerful instruments in the prevention of space motion sickness reside in the selection process and in acquiring adaptation-prelaunch. Today, neither of these means is practical. One logical alternative is to administer preventative medication to all or none. One candidate drug is a high-potency transdermal therapeutic system (TTS)-scopolamine. This is marketed in the nature of a patch that is affixed to the skin behind the ear 12 hr before need and delivers scopolamine into the blood stream for three days. We are systematically evaluating all claims for its high potency and low side effects. We are also evaluating new antimotion sickness remedies and new combinations of homergic drugs.

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A new goldfish model to evaluate pharmacokinetic and pharmacodynamic effects of drugs used for motion sickness in different gravity loads.

Lathers CM, Mukai C, Smith CM, Schraeder PL.

Center for Veterinary Medicine/FDA, Office of New Animal Drug Evaluation, Rockville, MD, USA.

This paper proposes a new goldfish model to predict pharmacodynamic/pharmacokinetic effects of drugs used to treat motion sickness administered in differing gravity loads. The assumption of these experiments is that the vestibular system is dominant in producing motion sickness and that the visual system is secondary or of small import in the production of motion sickness. Studies will evaluate the parameter of gravity and the contribution of vision to the role of the neurovestibular system in the initiation of motion sickness with and without pharmacologic agents. Promethazine will be studied first. A comparison of data obtained in different groups of goldfish will be done (normal vs. acutely and chronically bilaterally blinded vs. sham operated). Some fish will be bilaterally blinded 10 months prior to initiation of the experiment (designated the chronically bilaterally blinded group of goldfish) to evaluate the neuroplasticity of the nervous system and the associated return of neurovestibular function. Data will be obtained under differing gravity loads with and without a pharmacological agent for motion sickness. Experiments will differentiate pharmacological effects on vision vs. neurovestibular input to motion sickness. Comparison of data obtained in the normal fish and in acutely and chronically bilaterally blinded fish with those obtained in fish with intact and denervated otoliths will differentiate if the visual or neurovestibular system is dominant in response to altered gravity and/or drugs. Experiments will contribute to validation of the goldfish as a model for humans since plasticity of the central nervous system allows astronauts to adapt to the altered visual stimulus conditions of 0-g. Space motion sickness may occur until such an adaptation is achieved. c 2001. Elsevier Science Ltd. All rights reserved.

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Susceptibility to motion sickness induced by optokinetic rotation and self-rotation by walking around a vertical pole.

Hu S, Luo YJ.

Department of Psychology, Humboldt State University, Arcata, CA 95521, USA. sh4 axe.humboldt.edu

31 subjects viewed an optokinetic rotating drum for 12 min. in one session and self-rotated by walking quickly around a vertical pole with eyes closed while alternately flexing and extending the neck in another session. The self-rotation session contained 6 trials (3 clockwise and 3 counterclockwise rotations). Each trial contained 20 cycles of self-rotations. Self-reported ratings of nausea and symptoms of motion sickness were obtained for each session. The subjects developed symptoms of nausea, sweating, dizziness, headache, drowsiness, and changes in salivation in both drum rotation and self-rotation sessions. However, the subjects reported higher ratings of nausea in the session of optokinetic rotation than in the session of self-rotation around a vertical pole. These results indicated that both optokinetic rotation and self-rotation with eyes closed while alternately flexing and extending the neck are effective means of inducing nausea and motion sickness.

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