genital warts
Immunohistology of genital warts in different stages of regression after therapy with interferon gamma.

Fierlbeck G, Schiebel U, Muller C.

Universitats-Hautklinik Tubingen, BRD.

Twenty patients with papillomavirus-induced genital warts received pulsatory treatment with interferon gamma by subcutaneous injections in the abdominal skin. The condylomata regressed completely in 11 of the 20 patients analyzed. Sequential biopsies taken from genital warts and nonlesional skin were investigated by immunohistological techniques with the use of monoclonal antibodies against differentiation and HLA antigens to evaluate immunological effector mechanisms of condylomata regression. In all responders regression was shown to be associated with increasing dermal and epidermal infiltrates of activated CD4 and CD8 T lymphocytes, as well as with aberrant expression of HLA-DR and/or DY antigens on keratinocytes. Thus alteration of HLA class II antigen expression on keratinocytes in the presence of T lymphocytes is an important criterium for regression of genital warts.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2533570&dopt=Abstract genital wart


genital warts
[Anogenital warts in young children in hospital consultation in Lome (Togo). Role of transmission by sexual abuse]

[Article in French]

Pitche P, Kombate K, Gbadoe AD, Tchangai-Walla K.

Service de Dermatologie, Centre Hospitalier Universitaire Tokoin, Lome, Togo. ppitche yahoo.fr

The purpose of this 20-month prospective study conducted in the dermatology department of Lome Teaching Hospital was to determine the prevalence of sexual abuse in pre-adolescent children with anogenital warts. From May 1997 to December 1998, a total of 16 cases of anogenital warts were diagnosed in children under the age of 12 years. Sexual abuse was discovered in 8 cases. All 8 cases involved girls (mean age, 6.1 +/- 1.9 years). The mode of acquisition involved self-infection from non anogenital warts in three cases and contamination by the mother in three cases. In two cases the mode of acquisition could not be identified. The alleged abuser was a member of child's family in 3 cases, a household employee working at the child's home in three cases, a teacher in 1, and a neighbor in 1. Syphilitic tests were negative in all children. However HIV infection was detected and the contaminator was identified in one 10-year-old girl. The results of this study document the correlation between anogenital warts and sexual abuse. In Black Africa, the consequences of child sexual abuse, which is not uncommon especially in major cities, are aggravated by the high prevalence of HIV infection.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11582873&dopt=Abstract genital wart


genital warts
Prevalence of genital papillomavirus infection among women attending a college student health clinic or a sexually transmitted disease clinic.

Kiviat NB, Koutsky LA, Paavonen JA, Galloway DA, Critchlow CW, Beckmann AM, McDougall JK, Peterson ML, Stevens CE, Lipinski CM, et al.

Department of Medicine, Harborview Medical Center, University of Washington, Seattle.

We examined 454 women randomly selected from a Sexually Transmitted Disease (STD) Clinic and 545 consecutive college women undergoing annual examination. Patients were examined for visible genital warts, koilocytes, and human papillomavirus (HPV) antigen on cervical smears and for cervical HPV DNA types 6, 11, 16, 18, and 31. Genital warts were found in 11% of STD Clinic patients and 2% of students (P less than .001). Among those women without genital warts, HPV DNA or antigen was detected in cervical specimens from 10.6% of STD Clinic patients and 11.4% of students (P = .73), with HPV type 16, 18, or 31 being 9.8 times more frequent than cervical HPV 6 or 11 among students and 5.8 times more frequent among STD Clinic patients. Dysplasia was present in 53% of those with HPV type 6 or 11 and in 41% of those with HPV type 16, 18, or 31 DNA.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2536781&dopt=Abstract genital wart


genital warts
Cervical signs of HPV infection in PAP-smear negative women with external genital warts.

Petersen CS, Thomsen HK, Sondergaard J.

Department of Dermato-Venereology, Bispebjerg Hospital, University of Copenhagen, Denmark.

Forty-eight women with external genital warts, all with normal cervical cytological PAP smears, were examined by means of colposcopy. One cervical biopsy for histological evaluation was taken from each woman, irrespective of the colposcopic findings. Koilocytosis was detected in 18/48 (38%) and dysplasia (CIN-1) in 3/48 (6%) of the patients. The presence of aceto-white lesions on the cervix was significantly associated with abnormal histology; 12 of 17 (71%) aceto-white lesions and 8 to 31 (26%) normal-appearing cervices showed histological changes indicating HPV infection (p less than 0.01). Women with koilocytosis and dysplasia had genital warts for a mean of 201 days compared with 79 days in women with normal cervical histology (p less than 0.01). It is concluded that even the clinically normal appearing cervix frequently is a reservoir for HPV and that colposcopy should be a routine procedure in women with external genital warts, irrespective of the result of the PAP smear, to provide a basis for proper counselling and individual therapy.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2572122&dopt=Abstract genital wart


genital warts
Anogenital warts of the condyloma acuminatum type in HIV-positive patients.

Rudlinger R, Grob R, Buchmann P, Christen D, Steiner R.

Department of Dermatology, University Hospital, Zurich, Switzerland.

Anogenital warts of the condyloma acuminatum type seem to occur quite often during HIV infection. These warts--according to our study--are not commonly caused by malignancy-associated human papilloma virus types, but by types 6 and 11 as seen in the nonimmune-compromised population. Widespread condylomata acuminata may appear in rather early stages of HIV infection and they may therefore represent early warning signs of HIV infection.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2841174&dopt=Abstract genital wart