genital warts
A comparative study of topical analgesia with a lidocaine/prilocaine cream (EMLA) and infiltration anesthesia for laser surgery of genital warts in men.

Lassus A, Kartamaa M, Happonen HP.

Department of Venereology, University Central Hospital, Helsinki, Finland.

Treatment of genital warts by laser surgery was performed in 100 male patients under local infiltration (2-6 ml 1% Xylocaine) or topical anesthesia with 2.5-7.5 ml EMLA cream. EMLA cream was applied to the warts ten minutes before the operation. Pain was significantly less during application of EMLA than during infiltration of Xylocaine. Infiltration anesthesia resulted in better surgical analgesia than EMLA, although the difference was small. The combined pain scores of application and surgery were significantly smaller in the EMLA group. The result suggests that EMLA applied for ten minutes constitutes a less painful treatment and is thus the anesthetic of choice for the laser surgery of genital warts.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2247802&dopt=Abstract genital wart


genital warts
[Condylomata acuminata: immunological evaluation and interferon therapy]

[Article in Italian]

Donofrio P, Boccia L, Scalvenzi M, Delfino M, Cosentini E.

The distribution of peripheral blood T lymphocytes in 35 patients aged 16 to 49 years with genital warts was studied. Patients with genital warts were found to be less responsive than a control group, and this deficiency was related to duration of genital wart infection. 11 patients affected with long lasting genital warts were treated with interferon. The results are reported and briefly discussed.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2483403&dopt=Abstract genital wart


genital warts
The subtypes, distribution and location of human papillomavirus DNA in genital warts and genital Bowen's disease--a study using in situ DNA.DNA hybridization.

Jee SH, Chen Y, Chang SF, Ho SW, Wu YC, Wen WN, Lu YC.

Department of Dermatology, National Taiwan University Hospital, ROC.

The aim of this study is to investigate the difference in subtypes and distribution of human papillomavirus (HPV) between the benign pathological condition- Genital wart (condyloma acuminatum, verruca- like lesion and papular lesion) and genital Bowen's disease (Bowenoid papulosis, Mollucum contagiosum with Bowenoid papulosis and Condyloma acuminatum with verruca- like lesion and pathological bowenoid change) of genitalia by in situ DNA.DNA hybridization. In situ DNA.DNA hybridization was performed by hybridizing the RNAse treated and denatured frozen skin section with 3H-labeled HPV 6, 11, 16 and 18-DNAs probes and then developed autoradiogram on a glass slide. The results reveal that: (1) The benign cases are strongly associated with HPV 6/11, while the bowenoid cases are associated with HPV 16/18, indicating 16 positive in 24 cases and 3 positive in 5 cases respectively; (2) Four of sixteen benign cases were doubly infected with HPV 6/11 and 16/18; and 2 of 2 bowenoid cases were infected with HPV 16/18 only (3) In benign cases, HPV distributes through the upper third of epidermis and in bowenoid cases, HPV scatters throughout the whole epidermis including parabasal layers. These findings may indicate that the subtypes of HPV, the interaction of weak oncogenic virus (HPV 6/11) and strong oncogenic virus (HPV 16/18) and the presence of HPV on proliferating cells (parabasal layers) all play a part in oncogenicity. The detectability of HPV 6/11 DNA in both the nucleus and cytoplasm indicate that: 1). In situ DNA.DNA hybridization is a more sensitive method than the immunological detection of capsid antigen. 2). In addition to the nucleus, the cytoplasm is a site through which HPV 6/11 virus should pass during their life cycle. Using PEG hybridization mixture, it was revealed that 6 of the 6 HPV 6/11 positive condyloma acuminata harbored HPV 6. This result indicates that the subtype of HPV determine the gross morphology of skin lesion.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2561558&dopt=Abstract genital wart


genital warts
Clinical course of anogenital warts in men infected with human immunodeficiency virus.

McMillan A, Bishop PE.

Genitourinary Medicine Unit, Royal Infirmary, Edinburgh.

Fifty four men with anogenital warts were studied; 22 had concurrent infection with the human immunodeficiency virus (HIV). The median duration of the warts before and after the start of treatment of seven HIV infected and 10 non-infected heterosexual men was similar. In homosexual men, however, the duration of the lesions in 15 HIV infected patients was greater before and after treatment than in 22 non-HIV infected men. As the median number of CD4+ cells in the peripheral blood was significantly lower in homosexual than heterosexual men infected with HIV, the difference in the course of anogenital warts in homosexual compared with heterosexual men may reflect different degrees of immunosuppression.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2807279&dopt=Abstract genital wart


genital warts
Isoprinosine in the treatment of genital warts.

O'Neill BB, Robins DS.

Newport Pharmaceuticals International, Inc., Newport Beach, California.

Several modes of therapy are presently available for treatment of genital warts. These include use of keratolytics such as podophyllin or trichloroacetic acid, electrocoagulation, cryotherapy, and laser therapy. Responses have not been uniformly successful, however, and particularly in patients with resistant warts there is evidence of impairment of cell-mediated immunity (CMI). In the healing process both humoral and CMI responses are of importance, and indeed it has been reported that in patients with recalcitrant viral warts the lesions disappeared at the same time the CMI response returned to normal. Isoprinosine is an orally administered drug known to have both in vitro and in vivo immunopotentiating activity and has been shown previously to restore toward normal the depressed CMI responses of diverse etiology accompanying a variety of clinical conditions. Recent evidence implicating certain types of genital warts in later development of cervical cancer in females has led to the search for a more effective treatment of this condition. Clinical studies to date involving the use of isoprinosine alone or in combination appear to have established the role of this safe and easily administered oral drug in increasing the chances of total eradication of condylomatous lesions and sparing a high percentage of patients from having to undergo repeated and more traumatic therapies.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2460237&dopt=Abstract genital wart