Parasite. 1994 Mar;1(1):57-64.
Activity of albendazole-ivermectin combination and other filaricidal drugs against infective larvae, preadult, microfilariae and adult worms of Molinema dessetae in the rodent Proechimys oris.

Duarte Z, Gantier JC, Gayral P.

Faculte de Pharmacie, Universite de Paris Sud, Chatenay Malabry, France.

The efficacy of albendazole-ivermectin combination was tested an adult and developing stages of Molinema dessetae in the rodent Proechimys oris. Albendazole and ivermectin, both given alone, suramin and diethylcarbamazine were used as reference compounds. The drug combination (albendazole at 10 mg/kg/ day x 5 days and Ivermectin at 0.04 mg/kg/day x 5 days) was effective against infective larvae and preadult worms, and substantially reduced the number of live adult worms. The known filaricidal agents, diethylcarbamazine (400 mg/kg twice daily x 5 days), ivermectin (0.2 mg/kg/day x 5 days), and suramin (40 mg/kg/day x 5 days), as well as albendazole (50 mg/kg/day x 5 days) were active on infective larvae, preadult worms, microfilariae and adult worms. All drugs had the same level of efficacity on infective larvae. Albendazole had the highest efficacy against adult and preadult worms and diethylcarbamazine was the most active on microfilariae. Although the drug combination was not as effective against preadult and adult worms as albendazole alone, the results indicate that albendazole-ivermectin combination at a low dose had prophylactic effect and suggest a possible macrofilaricidal activity.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9140472&dopt=Abstract albendazole Albenza


Am J Vet Res. 1976 Dec;37(12):1515-6.
Efficacy of albendazole against Haemonchus, Nematodirus, Dictyocaulus, and Monieza of sheep.

Theodorides VJ, Nawalinski T, Chang J.

Albendazole was highly efficacious in the removal of monospecific and mixed infection of Haemonchus contortus, Nematodirus spathiger, and Dictyocaulus filaria from sheep. A dose level of 5 mg/kg removed nearly all gastrointestinal nematodes, and 10 mg/kg removed all lungworms. Tapeworms of the genus Moniezia were completely removed by a dose level of 10 hg/kg.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=136914&dopt=Abstract albendazole Albenza




Am J Vet Res. 1978 Jul;39(7):1107-8.
Anthelmintic efficacy of albendazole against adult Dictyocaulus viviparus in experimentally infected calves.

Benz GW, Ernst JV.

Anthelmintic activity of albendazole against adult Dictyocaulus viviparus was evaluated in a controlled experiment. Calves were raised nematode-free to approximately 8 weeks of age and were each given 4,000 infective 3rd-stage larvae. Twenty calves with patent parasitisms were allotted to 2 groups of 10 calves each. Calves in group 1 were used as nonmedicated controls, and calves in group 2 were given albendazole in paste formulation at the dosage concentration of 7.5 mg/kg of body weight on the 30th day after administration of infective larvae. At necropsy, nonmedicated control calves had a total of 308 adult D viviparus, whereas the albendazole-treated calves had 11, for an average efficacy of 96.4%. These reductions were statistically highly significant (P less than 0.01). At necropsy, none of the treated calves was passing 1st-stage C viviparus larvae in their feces, whereas control calves were passing an average of 46 larvae/10 g of feces.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=150241&dopt=Abstract albendazole Albenza




Aliment Pharmacol Ther. 1988 Aug;2(4):341-6.
Theophylline disposition--effects of cimetidine, mebendazole and albendazole.

Adebayo GI, Mabadeje AF.

Department of Pharmacology, College of Medicine, Lagos, Nigeria.

On the basis of the report that benzimidazoles bind to and inhibit the hepatic cytochrome P-450 enzyme system, the effect of mebendazole and albendazole on theophylline disposition was studied in 12 volunteers. Mebendazole at a dose of 100 mg b.d. for 3 days did not significantly alter the theophylline half-life, volume of distribution or clearance in a group of six. In another group of six adult volunteers, albendazole (400 mg) pretreatment did not alter the same parameters. However, in this second group, pretreatment with cimetidine (400 mg t.d.s. for 5 days) significantly increased theophylline half life from 7.7 to 9.8 +/- 1.5 h (P less than 0.001) and reduced its clearance from 0.8 to 0.60 +/- 0.1 ml min-1 kg-1 (P less than 0.005). The volume of distribution was not altered significantly. It is concluded that at therapeutic doses it is unlikely that mebendazole or albendazole will induce theophylline toxicity if co-administered with the bronchodilator. Cimetidine-induced impairment of theophylline metabolism is such that toxicity will be more likely in individuals with initial high theophylline clearance.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2979257&dopt=Abstract albendazole Albenza




Trans R Soc Trop Med Hyg. 1988;82(4):611-5.
Echinococcus multilocularis: in vivo results of therapy with albendazole and praziquantel.

Taylor DH, Morris DL, Richards KS, Reffin D.

Department of Surgery, University Hospital, Nottingham, UK.

The effects of albendazole and praziquantel on the growth of Echinococcus multilocularis were studied in cotton rats. Albendazole (20 and 50 mg/kg) reduced parasite weight and increased the length of survival of infected animals but viable infection was present after treatment. In an in vitro system albendazole sulphoxide entered cysts of E. multilocularis passively. Praziquantel 100 mg/kg was ineffective but 500 mg/kg significantly inhibited growth. A combination of albendazole and praziquantel was no more effective than either agent alone.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3076717&dopt=Abstract albendazole Albenza




Vet Parasitol. 1988 Jan;26(3-4):261-4.
Efficacy and safety of albendazole against experimentally induced Fasciola hepatica infections in goats.

Foreyt WJ.

Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164.

Forty 8-week-old goats were allocated to five groups of equal size to determine the optimal dosage of albendazole against experimentally induced 14-week-old Fasciola hepatica infections. Albendazole suspension given orally at 5.0, 7.5, 10.0 and 15 mg kg-1 of body weight was 73.3, 88.2, 88.3 and 95.9% effective, respectively, when compared to untreated controls. Mean number of F. hepatica in the untreated control goats was 75.4. No signs of toxicity were observed. When albendazole was given to eight, 8-week-old goats orally at 75 mg kg-1 (five times the optimal dosage), no signs of toxicity were observed.

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J Antimicrob Chemother. 1988 Jan;21(1):75-84.
Efficacy of albendazole against Strongyloides ratti and S. stercoralis in vitro, in mice, and in normal and immunosuppressed dogs.

Grove DI, Lumsden J, Northern C.

Department of Medicine, University of Western Australia, Sir Charles Gairdner Hospital, Queen Elizabeth II Medical Centre, Nedlands.

In view of conflicting clinical reports, the effects of albendazole on Strongyloides were examined in vitro and in experimentally-infected animals. Albendazole inhibited the hatching and moulting of S. ratti eggs and larvae and prevented the development in vitro of S. stercoralis first-stage larvae. Pre-exposure to the drug did not impair the infectivity of either S. ratti or S. stercoralis third-stage larvae. Albendazole had a dose-dependent inhibitory effect on S. ratti migrating larvae in mice when measured in terms of the numbers of larvae recovered from the skin or lungs or the subsequent development of a patent infection. Likewise, killing of adult S. ratti in the gut and eradication of S. stercoralis third-stage larvae from the muscles of mice were dose-dependent. Albendazole in a dose of 100 mg twice daily for three days given at the time of infection with S. stercoralis of immunocompetent dogs prevented completely the subsequent development of patent infection. When the drug was given in the same dosage to immunosuppressed dogs with patent infections, the larvae disappeared from the stools transiently; when the animals were killed seven weeks after treatment, small numbers of adult worms and rhabditiform larvae were found in the gut. It is concluded that albendazole may be effective treatment for strongyloidiasis if it is given in sufficiently large doses.

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Arch Neurol. 1988 May;45(5):532-4.
Albendazole vs praziquantel for therapy for neurocysticercosis. A controlled trial.

Sotelo J, Escobedo F, Penagos P.

Research Division, Instituto Nacional de Neurologia y Neurocirugia, Mexico City.

Praziquantel and albendazole have been recently described as effective drugs for treating cysticercosis of the brain. In this study, effectiveness of each drug for therapy for parenchymal brain cysticercosis was compared. Twenty patients were treated either with albendazole or with praziquantel; in addition, five patients were taken as controls and treated only with symptomatic drugs. Three months after therapy, results showed that both drugs, albendazole and praziquantel, were highly effective, as seen by the disappearance of cystic lesions in computed tomographic scans. All lesions in control patients remained unchanged. Albendazole, when compared with praziquantel, showed a 76% vs 73% disappearance of lesions, respectively. It was concluded that both drugs have similar equivalent efficacy and greatly improve the therapeutics of cysticercosis.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3358706&dopt=Abstract albendazole Albenza