Acta Chir Iugosl. 1989;36 Suppl 2:540-2.
[Drug and surgical therapy of hydatidosis]

[Article in Croatian]

Lalji P, Kostic L.

Surgical treatment of hydatidosis carries the risk of dissemination and recidives. In this paper authors present their experience with combined medico-surgical treatment with Albendazole in 13 patients. Ultrasound, computerized tomography and serological tests were used for diagnosis and follow-up. Microscopic viability test was used for the operated upon patients. In seven patients who were operated after two courses of Albendazole the viability test was negative. Three patients who received two courses of Albendazole after surgery did not show any recidive two years later. Another three patients who received only Albendazole (five courses) showed reduction in size and sings of calcification.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2618427&dopt=Abstract albendazole Albenza




Ann Trop Med Parasitol. 1989 Oct;83(5):485-8.
Albendazole is effective against established Echinococcus granulosus in gerbils: comparison of serum concentrations achieved by gavage and feed administration.

Taylor DH, Morris DL, Richards KS.

Department of Surgery, University Hospital, Nottingham, U.K.

Serum levels of albendazole sulphoxide in gerbils infected with Echinococcus granulosus and treated with albendazole (20 or 50 mg kg-1 day-1) by gavage were dose dependent, whereas albendazole administered in feed at a rate equivalent to 80 mg kg-1 day-1 achieved serum levels calculated to be equivalent to those produced by administration of 40 mg kg-1 day-1 by gavage. This regimen, over a three-month period, was effective and reduced parasite weight to 4.6% of that in control gerbils, and the treated parasite tissue showed ultrastructural changes ranging from severe accumulation of residual bodies to total disintegration of the germinal layer.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2619363&dopt=Abstract albendazole Albenza




Ann Trop Med Parasitol. 1989 Dec;83(6):621-4.
Effect of albendazole in experimental toxocariasis of mice.

Delgado O, Botto C, Mattei R, Escalante A.

Instituto de Medicina Tropical, Universidad Central de Venezuela, Caracas.

Fifty-five mice were each infected with 800 embryonated eggs of Toxocara canis. Beginning on the second day of the infection, one group received a single 9 mg dose of albendazole every 24 hours for an eight-day period while a second group received 3 mg of albendazole every eight hours for the same period. On the tenth day of infection, mice in each treatment group and their corresponding controls were sacrificed, and the presence and motility of T. canis larvae in the brain were determined. With both therapeutical procedures the administration of albendazole reduced the number of larvae which reach the brain. However, for the same total dose, the administration of the drug every eight hours yielded results which were significantly superior to those produced by administering a single dose every 24 hours, reducing both the number of larvae in the brain and their motility.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2619377&dopt=Abstract albendazole Albenza




Ann Trop Med Parasitol. 1989 Dec;83(6):625-9.
Evaluation of albendazole, pyrantel, bephenium, pyrantel-praziquantel and pyrantel-bephenium for single-dose mass treatment of necatoriasis.

Nahmias J, Kennet R, Goldsmith R, Greenberg Z.

Zevulun Clinic, Kupal Holim, Haifa, Israel.

An effective drug for single-dose mass treatment of necatoriasis was sought by testing three drugs and two drug combinations in Ethiopian immigrants to Israel found to have light infections. The drugs tested sequentially in single-doses were pyrantel pamoate (20 mg kg-1, 81 subjects); bephenium hydroxynaphthoate (2.5-5 g, 65 subjects); combined pyrantel and bephenium (25 subjects); combined pyrantel (20 mg kg-1) and praziquantel (40 mg kg-1) (16 subjects); and albendazole (400 mg, 77 subjects). Follow-up under conditions without likelihood of reinfection was by one stool examination. Cure rates with albendazole, pyrantel-bephenium and pyrantel-praziquantel were 84, 80 and 81% respectively; these rates were significantly higher than the 49% found for bephenium and the 51% for pyrantel (P less than 0.05). Egg reductions in those not cured were pyrantel (22%), bephenium (6%), pyrantel-bephenium (34%), pyrantel-praziquantel (3%) and albendazole (6%). Albendazole was the most promising single drug treatment; unexpected was the high effectiveness of pyrantel-praziquantel in combination.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2619378&dopt=Abstract albendazole Albenza




Chirality. 1989;1(2):142-53.
Direct separation of albendazole sulfoxide enantiomers by liquid chromatography on a chiral column deriving from (S)-N-(3,5-dinitrobenzoyl) tyrosine: application to enantiomeric assays on plasma samples.

Lienne M, Caude M, Rosset R, Tambute A, Delatour P.

Laboratoire de Chimie Analytique de l'Ecole Superieure de Physique et Chimie Industrielles de Paris, France.

The direct enantiomeric resolution of albendazole sulfoxide (SOABZ), an anthelmintic drug belonging to the benzimidazole class, is reported on a chiral stationary phase (CSP) synthesized by covalent binding of (S)-N-(3,5-dinitrobenzoyl)tyrosine-O-(2-propen-1-yl) methyl ester on a gamma-mercaptopropyl-silanized silica gel. A comparison with the resolution achieved on commercially available Pirkle-type CSPs obtained from N-(3,5-dinitrobenzoyl) derivatives of (R)-phenyglycine or (S)-phenylalanine is described. Some structurally related chiral sulfoxides including oxfendazole (SOFBZ) are also studied. Optimization of the mobile phase nature and composition is investigated showing that a hexane-dioxane-ethanol ternary mixture affords an almost baseline resolution (Rs = 1.25); however, in this case, albendazole sulfone (SO2ABZ) is eluted between the two sulfoxide enantiomers; accordingly, a hexane-ethanol mobile phase would be preferred for biological samples containing both metabolites. The influence of temperature on the resolution is depicted with a hexane-ethanol mobile phase. Finally, application to the enantiomeric assays of SOABZ in plasmatic extracts of rat, sheep, bovin, and man after oral administration of albendazole (sulfoxidized to SOABZ and SO2ABZ) is reported. Some distortions in the enantiomeric ratios are evidenced depending on the species.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2642043&dopt=Abstract albendazole Albenza




Aust N Z J Surg. 1989 Dec;59(12):933-6.
Albendazole treatment of recurrent hydatid disease: serial evaluation with ultrasound.

Cossetto D, Gruenewald S, Antico V, Little JM.

Department of Surgery, Westmead Hospital, New South Wales, Australia.

Four patients with complex abdominal hydatid cysts, one of whom also had pulmonary and pelvic involvement, were treated with up to six 28-day courses of albendazole 400 mg per oral twice daily. As part of a prospective study, serial ultrasound scanning was performed after each 28-day course of albendazole and showed evidence of remission of disease in all four patients. Transient minor abnormalities of liver function were noted during treatment. Ultrasound scanning showed the disappearance of daughter cysts and cystic septation, increase in echogenicity and marked reduction in cyst size. Consolidation of these changes and, in some cases, disappearance of the cysts, were noted with continued therapy. Albendazole seems to be a safe and effective agent in the treatment of recurrent hydatid disease, exerting most of its cysticidal activity within the first 2-3 months of therapy.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2688625&dopt=Abstract albendazole Albenza




Vet Parasitol. 1989 Jan;30(3):213-22.
The effect of levamisole and albendazole on some enzymes of Ascaridia galli and Heterakis gallinae.

Sharma RK, Singh K, Saxena KK.

Postgraduate Department of Zoology, Bareilly College, India.

Ascaridia galli and Heterakis gallinae obtained from the common fowl Gallus gallus were exposed to 10(-2)-10(-5)M levamisole and albendazole; both compounds caused death of the parasites in vitro. The effect of the drugs was investigated on homogenates of the treated worms. Albendazole, at 10(-2)M, inhibited oxaloacetate reduction by 67 and 53% and malate oxidation by 21 and 17% in A. galli and H. gallinae, respectively, whereas 10(-4)M levamisole completely inhibited malate dehydrogenase activity in both directions in the two parasites. Lactate dehydrogenase was not affected significantly by either anthelmintic. Aldolase activity was diminished by 57 and 32% in A. galli and H. gallinae, respectively, with 10(-4)M levamisole. Levamisole at 10(-4)M also inhibited the activity of acid and alkaline phosphomonoesterase and cholinesterase. Albendazole had no significant effect on these enzymes in either parasite. Malate dehydrogenase and cholinesterase activity of the host tissue (intestine and caecum) was also reduced significantly with 10(-2) and 10(-3)M levamisole. These studies indicated a multiple mode of action of levamisole and albendazole.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2705287&dopt=Abstract albendazole Albenza