Tidsskr Nor Laegeforen. 1991 Jan 20;111(2):193-5.
[Dependence on carisoprodol (Somadril)? A prospective withdrawal study among prisoners]

[Article in Norwegian]

Wyller TB, Korsmo G, Gadeholt G.

Helsetjenesten ved Ila landsfengsel og sikringsanstalt, Oslo.

Carisoprodol (Somadril) was gradually withdrawn for a fortnight in nine male prisoners who had been taking daily doses of from 700 to 2,100 mg for at least nine months. The patients were assessed clinically during the withdrawal period, with special attention to the occurrence of abstinence symptoms. Most of the patients reported mental distress, such as anxiety, insomnia and irritability. Cranial and muscular pain and vegetative symptoms were also frequently reported. Most of these symptoms were transient, and no seizures or psychotic reactions occurred. Our information from drug addicts indicates that carisoprodol can be misused as a narcotic. The occurrence of abstinence symptoms during withdrawal supports this supposition. We propose a more gradual reduction of the doses when terminating medication with carisoprodol in general practice.

Source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1998178&dopt=Abstract soma carisoprodol




J Agric Food Chem. 2005 Mar 9;53(5):1625-32.
Human pharmaceuticals, hormones, and personal care product ingredients in runoff from agricultural fields irrigated with treated wastewater.

Pedersen JA, Soliman M, Suffet IH.

Molecular and Environmental Toxicology Center and Department of Soil Science, University of Wisconsin, Madison, Wisconsin 53706, USA.

Irrigation of crops with treated wastewater has the potential to introduce effluent-derived organic microcontaminants into surface waters through agricultural runoff. To determine whether compounds indicative of the presence of treated effluent in irrigation water could be identified in agricultural runoff, surface runoff samples collected from effluent-irrigated and rain-fed cultivated fields were analyzed for a broad spectrum of organic compounds. A variety of compounds was identified that appeared to be associated with irrigation with treated wastewater. These compounds included human pharmaceuticals (e.g., carbamazepine, gemfibrozil, carisoprodol), personal care product ingredients (e.g., insect repellent, polycyclic musks), and alkyl phosphate flame retardant chemicals. Most of these compounds appear not to have been previously reported in agricultural runoff. These compounds were present at concentrations below the few published aquatic toxicology data available; however, their potential to elicit more subtle effects in aquatic organisms cannot be excluded. None of these compounds were detected by broad-spectrum analysis in samples from the same fields during runoff-producing rain events.

Source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15740050&dopt=Abstract soma carisoprodol




J Anal Toxicol. 1988 Mar-Apr;12(2):73-4.
A rapid and sensitive gas chromatographic analysis of meprobamate or carisoprodol in urine and plasma.

Kintz P, Mangin P, Lugnier AA, Chaumont AJ.

Institute de Medicine Legale, Strasbourg, France.

A method for the identification and quantification of meprobamate or carisoprodol in plasma by GC/FID is presented. The method employs vinylbarbital as the internal standard and requires no derivatization. After a single extraction, analysis is achieved in 7 min. This method is thus rapid, sensitive, reproducible, selective, and applicable to forensic and clinical toxicological analyses.

Source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3379924&dopt=Abstract soma carisoprodol




Am J Clin Pathol. 2002 Mar;117(3):396-400.
Carisoprodol: an unrecognized drug of abuse.

Bailey DN, Briggs JR.

Department of Pathology, University of California, San Diego 92103-8320, USA.

During a 6-month monitoring period, carisoprodol was detected in the urine specimens of 19 patients for whom drug screening had been ordered for purposes of patient care. The clinical history suggested that in 7 cases the drug was abused or implicated in a suicide attempt or gesture. In another 7 cases, the drug was used primarily for medical purposes, and in 5 cases the reason for use could not be determined. One patient ingested homemade tablets that were found to contain carisoprodol. In an additional case, the drug was detected in breast milk. Physical findings, clinical history, and treatment are described, and the profile of a typical carisoprodol user is discussed. It seems that carisoprodol has become an unrecognized drug of abuse, at least in our community. This drug and its metabolite, meprobamate, should be included in comprehensive drug screening.

Source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11888078&dopt=Abstract soma carisoprodol