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Uses Xenical is used with a reduced-calorie diet to help significantly overweight persons lose weight. It also helps to prevent regaining weight previously lost. Orlistat works by blocking some of the fat normally digested by the intestine. How To Use Take Xenical by mouth, generally three times daily during (or up to one hour after) each main meal that contains fat. Your daily intake of fat, protein and carbohydrate should be evenly spread over three main meals. If a meal is occasionally missed or contains no fat, skip that dose of the medication. Because Xenical can interfere with absorption of fat-soluble vitamins (e.g., A,D,E,K), a daily multivitamin supplement containing these nutrients is recommended. Take the multivitamin at least 2 hours before or 2 hours after Xenical (e.g., at bedtime). The effects of Xenical may begin as soon as 1-2 days after treatment begins; noticeable weight loss will take longer. Side Effects Fatty/oily stool, oily spotting, intestinal gas with discharge, bowel movement urgency, poor bowel control, or headaches may occur. If these effects persist or worsen, notify your doctor promptly. Intestinal side effects (e.g., oily stool) may increase in intensity if you exceed your daily dietary fat allowance. Tell your doctor immediately if you have any of these unlikely but serious side effects: swelling of the feet or ankles. If you notice other effects not listed above, contact your doctor or pharmacist. Precautions Tell your doctor your medical history, including: allergies, digestive disorders (malabsorption or cholestasis), low thyroid function (hypothyroidism), other metabolism problems (e.g., oxalate kidney stones, hyperoxaluria). Xenical should not be used if you have anorexia nervosa or bulemia-type eating disorders. Tell your doctor if you are pregnant before using Xenical. The manufacturer does not recommend use of Xenical during pregnancy. It is not known whether Xenical is excreted into breast milk. Because of the potential risk to the infant, breast-feeding while using Xenical is not recommended. Consult your doctor before breast-feeding. Overdose If overdose is suspected, contact your local poison control center or emergency room immediately. Notes Do not share Xenical with others. Follow your doctor-approved nutritional, reduced-calorie diet containing about 30 percent calories from fat. Also, exercise is recommended; however, first consult your doctor or pharmacist. Missed Dose If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up. Storage Store at room temperature (77 degrees F, 25 degrees C) away from light and moisture.
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