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Uses
Rozerem (ramelteon) is a medication used to treat insomnia characterized by difficulty with sleep onset. Rozerem is the first prescription insomnia medication with a new therapeutic mechanism of action in decades, and can be prescribed for long-term use in adults. Rozerem is also the first and only prescription sleep medication that has shown no evidence of abuse and dependence in clinical studies. As a result, Rozerem is not designated as a controlled substance by the U.S. Drug Enforcement Administration (DEA).
Disclaimer
This online drug information for Rozerem (ramelteon) is for your information purposes only. It is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your Rozerem medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibilities for the accuracy and reliability of this information, and/or any consequences arising from the use of this information pertaining to Rozerem (and any other drug information on other web pages in this web site) including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.
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Rozerem (ramelteon) References
Melatonin and sleep in aging population. Exp Gerontol. 2005 Sep 22
Ramelteon (TAK-375), a selective MT1/MT2-receptor agonist, reduces latency to persistent sleep in a model of transient insomnia related to a novel sleep environment. Sleep. 2005 Mar 1;28(3):303-7.
Recent advances in melatonin receptor ligands. Arch Pharm (Weinheim). 2005 Jun;338(5-6):229-47.
Ramelteon: TAK 375.(Review). Drugs R D. 2005;6(3):186-8.
Neurochemical properties of ramelteon (TAK-375), a selective MT1/MT2 receptor agonist. Neuropharmacology. 2005 Feb;48(2):301-10.
TAK-375 Takeda. (Review). Curr Opin Investig Drugs. 2005 Jan;6(1):114-21. TAK-375 (Ramelteon), a melatonin ML1/MT1 receptor agonist for the potential treatment of primary insomnia, is being developed by Takeda. Takeda submitted an NDA to the FDA for TAK-375 in September 2004.
Ramelteon (TAK-375) accelerates reentrainment of circadian rhythm after a phase advance of the light-dark cycle in rats. J Biol Rhythms. 2005 Feb;20(1):27-37.
The sleep-promoting action of ramelteon (TAK-375) in freely moving cats. Sleep. 2004 Nov 1;27(7):1319-25.
Effects of ramelteon (TAK-375) on nocturnal sleep in freely moving monkeys. Brain Res. 2004 Nov 19;1027(1-2):59-66.
Melatonin, sleep, and circadian rhythms: rationale for development of specific melatonin agonists. (Review). Sleep Med. 2004 Nov;5(6):523-32.
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